Effect of Bakumondo-to on cytochrome P450 activities in rat liver microsomes

被引：0

作者：

Yasuhara, Masako ^{[1
,2
]}

Tayama, Yoshitaka ^{[1
,3
]}

Kashiwagi, Takehiro ^{[3
]}

Sawa, Akihiro ^{[1
,3
]}

Kihira, Kenji ^{[1
,3
]}

Miyake, Katsushi ^{[1
,3
]}

机构：

[1] Hiroshima Int Univ, Grad Sch Pharmaceut Sci, 5-1-1 Hirokoshingai, Kure, Hiroshima 7370112, Japan

[2] Onomichi Gen Hosp, Dept Pharm, 1-10-23 Hirahara, Onomichi, Hiroshima 7228508, Japan

[3] Hiroshima Int Univ, Fac Pharmaceut Sci, 5-1-1 Hirokoshingai, Kure, Hiroshima 7370112, Japan

来源：

JOURNAL OF KING SAUD UNIVERSITY SCIENCE | 2016年 / 28卷 / 02期

关键词：

Bakumondo-to; CYP1A2; CYP2C; CYP3A; Interaction; ST-JOHNS-WORT; KAMPO MEDICINE; PHARMACOKINETICS; METABOLISM; THEOPHYLLINE; CYP3A4;

D O I：

10.1016/j.jksus.2016.02.003

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bakumondo-to is a traditional herbal medicine. It has been widely used for the treatment of chronic airway diseases. Recently, it was reported that several herbal medicines affected cytochrome P450 (CYP). However, there is little information about the effects of Bakumondo-to on CYP activities. In this study, we evaluated the effects of Bakumondo-to on CYP activities in rat liver microsomes. Rats were orally treated twice a day with Bakumondo-to at doses of 2.0 g/kg body weight/day for 4 days. CYP activities were determined in liver microsomes isolated from treated rats. CYP1A2, CYP2C, and CYP3A activities were measured using their specific substrates [7-methoxyresorufin, 7-methoxy-4-(trifluoromethyl)-coumarin, and 7-benzyloxyquinoline, respectively]. Bakumondo-to decreased CYP1A2 activity by 42.5 +/- 7.8%, increased CYP2C activity by 158.0 +/- 29.6%, and decreased CYP3A activity to 81.5 +/- 7.8% of the control level. Activities were expressed as percentages of the control. Bakumondo-to induced CYP2C activity and decreased CYP1A2 activity; it may cause drug-herbal interactions. It is suggested that combinations of Bakumondo-to and drugs that are metabolized by CYP1A2 and CYP2C should be carefully used in clinical settings. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：198 / 202

页数：5

共 23 条

[1] Evaluation of potential drug- herb interactions among a group of Palestinian patients with chronic diseases [J].

Al-Ramahi, Rowa' ;

Jaradat, Nidal ;

Shalalfeh, Ruba ;

Nasir, Sojoud ;

Manasra, Yazan ;

Shalalfeh, Ihab ;

Esam, Yasmen .

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, 15

[2] Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions [J].

Backman, Janne T. ;

Filppula, Anne M. ;

Niemi, Mikko ;

Neuvonen, Pertti J. .

PHARMACOLOGICAL REVIEWS, 2016, 68 (01) :168-241

[3] In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1 [J].

Chang, TKH ;

Chen, J ;

Benetton, SA .

DRUG METABOLISM AND DISPOSITION, 2002, 30 (04) :378-384

[4] Pharmacokinetic profile of zafirlukast [J].

Dekhuijzen, PNR ;

Koopmans, PP .

CLINICAL PHARMACOKINETICS, 2002, 41 (02) :105-114

[5] Multiple forms of human p450 expressed in Saccharomyces cerevisiae [J].

Imaoka, S ;

Yamada, T ;

Hiroi, T ;

Hayashi, K ;

Sakaki, T ;

Yabusaki, Y ;

Funae, Y .

BIOCHEMICAL PHARMACOLOGY, 1996, 51 (08) :1041-1050

[6] Antitussive effect of bakumondoto a fixed kampo medicine (six herbal components) for treatment of post-infectious prolonged cough: Controlled clinical pilot study with 19 patients [J].

Irifune, Kazunori ;

Hamada, Hironobu ;

Ito, Ryoji ;

Katayama, Hitoshi ;

Watanabe, Akira ;

Kato, Aki ;

Miyoshi, Seigo ;

Hamaguchi, Naohiko ;

Toyozawa, Ryo ;

Hamaguchi, Sachiko ;

Abe, Masahiro ;

Nishimura, Kazutaka ;

Higaki, Jitsuo .

PHYTOMEDICINE, 2011, 18 (8-9) :630-633

[7]

Ishohama Y., 2001, BAKUMONDO TO INCREAS, V18, P8

[8] Interactions between herbal medicines and prescribed drugs - A systematic review [J].

Izzo, AA ;

Ernst, E .

DRUGS, 2001, 61 (15) :2163-2175

[9] CYP2C8 but not CYP3A4 is important in the pharmacokinetics of montelukast [J].

Karonen, Tiina ;

Neuvonen, Pertti J. ;

Backman, Janne T. .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 73 (02) :257-267

[10]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

← 1 2 3 →