Photodynamic Effect in Near-IR Light by a Photocytotoxic Iron(III) Cellular Imaging Agent

被引：118

作者：

Basu, Uttara ^{[2
]}

Khan, Imran ^{[1
]}

Hussain, Akhtar ^{[2
]}

Kondaiah, Paturu ^{[1
]}

Chakravarty, Akhil R. ^{[2
]}

机构：

[1] Indian Inst Sci, Dept Mol Reprod Dev & Genet, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 11期

关键词：

antitumor agents; bioinorganic chemistry; cancer; iron; photodynamic therapy; CATECHOL DIOXYGENASES; FUNCTIONAL MODELS; VISIBLE-LIGHT; DNA CLEAVAGE; COMPLEXES; THERAPY; LIGANDS;

D O I：

10.1002/anie.201108360

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A red light for cancer cells: An iron(III) complex (1, see picture) that contains an anthracenyl fluorophore moiety and a catecholate ligand is a potent, metal-based PDT agent that efficiently photocleaves DNA in near-infrared light, has significant nuclear uptake, and high photocytotoxicity in red light by an apoptotic pathway in HeLa and MCF-7 cancer cells. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：2658 / 2661

页数：4

相关论文

共 29 条

[1] Dirhodium(II,II) complexes: Molecular characteristics that affect in vitro activity [J].

Angeles-Boza, Alfredo M. ;

Chifotides, Helen T. ;

Aguirre, J. Dafhne ;

Chouai, Abdellatif ;

Fu, Patty K. -L. ;

Dunbar, Kim R. ;

Turro, Claudia .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (23) :6841-6847

[2] Mononuclear iron(III) complexes of 3N ligands in organized assemblies: spectral and redox properties and attainment of regioselective extradiol dioxygenase activity [J].

Anitha, Natarajan ;

Palaniandavar, Mallayan .

DALTON TRANSACTIONS, 2011, 40 (09) :1888-1901

[3]

[Anonymous], 2010, ANGEW CHEM INT ED, V49, P8905

[4]

[Anonymous], 2010, ANGEW CHEM

[5]

Bonnett Alastair., 2000, ANTIRACISM

[6] Iron(III)-catecholato complexes as structural and functional models of the intradiol-cleaving catechol dioxygenases [J].

Bruijnincx, Pieter C. A. ;

Lutz, Martin ;

Spek, Anthony L. ;

Hagen, Wilfred R. ;

van Koten, Gerard ;

Gebbink, Robertus J. M. Klein .

INORGANIC CHEMISTRY, 2007, 46 (20) :8391-8402

[7] Oxidative nucleobase modifications leading to strand scission [J].

Burrows, CJ ;

Muller, JG .

CHEMICAL REVIEWS, 1998, 98 (03) :1109-1151

[8] Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization [J].

Celli, Jonathan P. ;

Spring, Bryan Q. ;

Rizvi, Imran ;

Evans, Conor L. ;

Samkoe, Kimberley S. ;

Verma, Sarika ;

Pogue, Brian W. ;

Hasan, Tayyaba .

CHEMICAL REVIEWS, 2010, 110 (05) :2795-2838

[9] Interactions of metal-metal-bonded antitumor active complexes with DNA fragments and DNA [J].

Chifotides, HT ;

Dunbar, KR .

ACCOUNTS OF CHEMICAL RESEARCH, 2005, 38 (02) :146-156

[10] A comparative study of the photosensitizing characteristics of some cyanine dyes [J].

Delaey, E ;

van Laar, F ;

De Vos, D ;

Kamuhabwa, A ;

Jacobs, P ;

de Witte, P .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2000, 55 (01) :27-36