Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease

被引:31
作者
Mead, Adam J. [1 ]
Gale, Rosemary E. [1 ]
Hills, Robert K. [1 ]
Gupta, Manu [1 ]
Young, Bryan D. [1 ]
Burnett, Alan K. [1 ]
Linch, David C. [1 ]
机构
[1] UCL, Inst Canc, Dept Hematol, London WC1E 6DD, England
基金
英国医学研究理事会;
关键词
D O I
10.1182/blood-2008-02-140392
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:444 / 445
页数:2
相关论文
共 10 条
[1]   The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia [J].
Gale, Rosemary E. ;
Green, Claire ;
Allen, Christopher ;
Mead, Adam J. ;
Burnett, Alan K. ;
Hils, Robert K. ;
Linch, David C. .
BLOOD, 2008, 111 (05) :2776-2784
[2]  
GUPTA M, 2008, GENES CHROMOSOMES CA
[3]   FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia [J].
Mead, Adam J. ;
Linch, David C. ;
Hills, Robert K. ;
Wheatley, Keith ;
Burnett, Alan K. ;
Gale, Rosemary E. .
BLOOD, 2007, 110 (04) :1262-1270
[4]   Clinical implications of FLT3 mutations in pediatric AML [J].
Meshinchi, Soheil ;
Alonzo, Todd A. ;
Stirewalt, Derek L. ;
Zwaan, Michel ;
Zimmerman, Martin ;
Reinhardt, Dirk ;
Kaspers, Gertjan J. L. ;
Heerema, Nyla A. ;
Gerbing, Robert ;
Lange, Beverly J. ;
Radich, Jerald P. .
BLOOD, 2006, 108 (12) :3654-3661
[5]   Rapid and sensitive detection of internal tandem duplication and activating loop mutations of FLT3 [J].
Mills, KI ;
Gilkes, AF ;
Walsh, V ;
Sweeney, M ;
Gale, R .
BRITISH JOURNAL OF HAEMATOLOGY, 2005, 130 (02) :203-208
[6]  
Raghavan M, 2005, CANCER RES, V65, P375
[7]   Heterogeneous patterns of FLT3 ASP835 mutations in relapsed de novo acute myeloid leukemia:: A comparative analysis of 120 paired diagnostic and relapse bone marrow samples [J].
Shih, LY ;
Huang, CF ;
Wu, JH ;
Wang, PN ;
Lin, TL ;
Dunn, P ;
Chou, MC ;
Kuo, MC ;
Tang, CC .
CLINICAL CANCER RESEARCH, 2004, 10 (04) :1326-1332
[8]   Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia:: association with FAB subtypes and identification of subgroups with poor prognosis [J].
Thiede, C ;
Steudel, C ;
Mohr, B ;
Schaich, M ;
Schäkel, U ;
Platzbecker, U ;
Wermke, M ;
Bornhäuser, M ;
Ritter, M ;
Neubauer, A ;
Ehninger, G ;
Illmer, T .
BLOOD, 2002, 99 (12) :4326-4335
[9]  
Whitman SP, 2001, CANCER RES, V61, P7233
[10]   FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications [J].
Whitman, Susan P. ;
Ruppert, Amy S. ;
Radmacher, Michael D. ;
Mrozek, Krzysztof ;
Paschka, Peter ;
Langer, Christian ;
Baldus, Claudia D. ;
Wen, Jing ;
Racke, Frederick ;
Powell, Bayard L. ;
Kolitz, Jonathan E. ;
Larson, Richard A. ;
Caligiuri, Michael A. ;
Marcucci, Guido ;
Bloomfield, Clara D. .
BLOOD, 2008, 111 (03) :1552-1559