Persistent SARS-CoV-2 infection in asymptomatic young adults

被引：14

作者：

Ma, Mai-Juan ^{[1
]}

Qiu, Shao-Fu ^{[2
]}

Cui, Xiao-Ming ^{[1
]}

Ni, Ming ^{[3
]}

Liu, Hong-Jie ^{[3
]}

Ye, Run-Ze ^{[1
,4
]}

Yao, Lin ^{[1
]}

Liu, Hong-Bo ^{[2
]}

Cao, Wu-Chun ^{[1
]}

Song, Hong-Bin ^{[2
]}

机构：

[1] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

[2] Chinese Peoples Liberat Army, Ctr Dis Control & Prevent, Beijing, Peoples R China

[3] Beijing Inst Radiat Med, Beijing, Peoples R China

[4] Shandong Univ, Sch Publ Hlth, Jinan, Peoples R China

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2022年 / 7卷 / 01期

基金：

北京市自然科学基金;

关键词：

D O I：

10.1038/s41392-022-00931-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intra-host evolution of SARS-CoV-2 has not been reported among asymptomatic cases, though this phenomenon was observed in a few symptomatic and immunocompromised cases. Here, we identified six asymptomatic cases who were persistently positive for SARS-CoV-2 RNA up to 120 days. Phylogenetic analysis of 40 serial whole-genome sequences from the six cases revealed dynamic mutations of the virus. To explore the possible mechanism contributing to the persistent infection, we investigated immune responses. The six cases had comparable specific antibodies with other 24 non-persistent asymptomatic cases, but they had significantly lower antibody levels than symptomatic cases. Although the virus-specific memory B and T cells were detected in the three groups of cases, the six cases showed an upregulation of CD4 regulatory T cells, which was negatively correlated with low levels of activated CD4(+) and CD8(+) T cells. These findings imply that dysregulation of immune responses might contribute to persistent infection.

引用

页数：4

共 7 条

[1] Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer [J].

Avanzato, Victoria A. ;

Matson, M. Jeremiah ;

Seifert, Stephanie N. ;

Pryce, Rhys ;

Williamson, Brandi N. ;

Anzick, Sarah L. ;

Barbian, Kent ;

Judson, Seth D. ;

Fischer, Elizabeth R. ;

Martens, Craig ;

Bowden, Thomas A. ;

de Wit, Emmie ;

Riedo, Francis X. ;

Munster, Vincent J. .

CELL, 2020, 183 (07) :1901-+

[2] Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient [J].

Baang, Ji Hoon ;

Smith, Christopher ;

Mirabelli, Carmen ;

Valesano, Andrew L. ;

Manthei, David M. ;

Bachman, Michael A. ;

Wobus, Christiane E. ;

Adams, Michael ;

Washer, Laraine ;

Martin, Emily T. ;

Lauring, Adam S. .

JOURNAL OF INFECTIOUS DISEASES, 2021, 223 (01) :23-27

[3] Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host [J].

Choi, Bina ;

Choudhary, Manish C. ;

Regan, James ;

Sparks, Jeffrey A. ;

Padera, Robert F. ;

Qiu, Xueting ;

Solomon, Isaac H. ;

Kuo, Hsiao-Hsuan ;

Boucau, Julie ;

Bowman, Kathryn ;

Das Adhikari, U. ;

Winkler, Marisa L. ;

Mueller, Alisa A. ;

Hsu, Tiffany Y. -T. ;

Desjardins, Michael ;

Baden, Lindsey R. ;

Chan, Brian T. ;

Walker, Bruce D. ;

Lichterfeld, Mathias ;

Brigl, Manfred ;

Kwon, Douglas S. ;

Kanjilal, Sanjat ;

Richardson, Eugene T. ;

Jonsson, A. Helena ;

Alter, Galit ;

Barczak, Amy K. ;

Hanage, William P. ;

Yu, Xu G. ;

Gaiha, Gaurav D. ;

Seaman, Michael S. ;

Cernadas, Manuela ;

Li, Jonathan Z. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) :2291-2293

[4] SARS-CoV-2 evolution during treatment of chronic infection [J].

Kemp, Steven A. ;

Collier, Dami A. ;

Datir, Rawlings P. ;

Ferreira, Isabella A. T. M. ;

Gayed, Salma ;

Jahun, Aminu ;

Hosmillo, Myra ;

Rees-Spear, Chloe ;

Mlcochova, Petra ;

Lumb, Ines Ushiro ;

Roberts, David J. ;

Chandra, Anita ;

Temperton, Nigel ;

Sharrocks, Katherine ;

Blane, Elizabeth ;

Modis, Yorgo ;

Leigh, Kendra E. ;

Briggs, John A. G. ;

van Gils, Marit J. ;

Smith, Kenneth G. C. ;

Bradley, John R. ;

Smith, Chris ;

Doffinger, Rainer ;

Ceron-Gutierrez, Lourdes ;

Barcenas-Morales, Gabriela ;

Pollock, David D. ;

Goldstein, Richard A. ;

Smielewska, Anna ;

Skittrall, Jordan P. ;

Gouliouris, Theodore ;

Goodfellow, Ian G. ;

Gkrania-Klotsas, Effrossyni ;

Illingworth, Christopher J. R. ;

McCoy, Laura E. ;

Gupta, Ravindra K. .

NATURE, 2021, 592 (7853) :277-+

[5] Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus [J].

Korber, Bette ;

Fischer, Will M. ;

Gnanakaran, Sandrasegaram ;

Yoon, Hyejin ;

Theiler, James ;

Abfalterer, Werner ;

Hengartner, Nick ;

Giorgi, Elena E. ;

Bhattacharya, Tanmoy ;

Foley, Brian ;

Hastie, Kathryn M. ;

Parker, Matthew D. ;

Partridge, David G. ;

Evans, Cariad M. ;

Freeman, Timothy M. ;

de Silva, Thushan, I ;

McDanal, Charlene ;

Perez, Lautaro G. ;

Tang, Haili ;

Moon-Walker, Alex ;

Whelan, Sean P. ;

LaBranche, Celia C. ;

Saphire, Erica O. ;

Montefiori, David C. .

CELL, 2020, 182 (04) :812-+

[6] Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19) [J].

van Kampen, Jeroen J. A. ;

van de Vijver, David A. M. C. ;

Fraaij, Pieter L. A. ;

Haagmans, Bart L. ;

Lamers, Mart M. ;

Okba, Nisreen ;

van den Akker, Johannes P. C. ;

Endeman, Henrik ;

Gommers, Diederik A. M. P. J. ;

Cornelissen, Jan J. ;

Hoek, Rogier A. S. ;

van der Eerden, Menno M. ;

Hesselink, Dennis A. ;

Metselaar, Herold J. ;

Verbon, Annelies ;

de Steenwinkel, Jurriaan E. M. ;

Aron, Georgina I. ;

van Gorp, Eric C. M. ;

van Boheemen, Sander ;

Voermans, Jolanda C. ;

Boucher, Charles A. B. ;

Molenkamp, Richard ;

Koopmans, Marion P. G. ;

Geurtsvankessel, Corine ;

van der Eijk, Annemiek A. .

NATURE COMMUNICATIONS, 2021, 12 (01)

[7] Virological assessment of hospitalized patients with COVID-2019 (vol 581, pg 465, 2020) [J].

Wolfel, Roman ;

Corman, Victor M. ;

Guggemos, Wolfgang ;

Seilmaier, Michael ;

Zange, Sabine ;

Muller, Marcel A. ;

Niemeyer, Daniela ;

Jones, Terry C. ;

Vollmar, Patrick ;

Rothe, Camilla ;

Hoelscher, Michael ;

Bleicker, Tobias ;

Brunink, Sebastian ;

Schneider, Julia ;

Ehmann, Rosina ;

Zwirglmaier, Katrin ;

Drosten, Christian ;

Wendtner, Clemens .

NATURE, 2020, 588 (7839) :E35-E35

← 1 →