Effect of whey protein consumption on IL-6 and TNF-α: A systematic review and meta-analysis of randomized controlled trials

被引：7

作者：

Jamshidi, Sanaz ^{[1
]}

Mohsenpour, Mohammad Ali ^{[2
]}

Masoumi, Seyed Jalil ^{[3
,4
,5
]}

Fatahi, Somayeh ^{[1
]}

Nasimi, Nasrin ^{[3
]}

Zahabi, Elham Sharifi ^{[1
]}

Pourrajab, Behnaz ^{[1
]}

Shidfar, Farzad ^{[1
]}

机构：

[1] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran

[2] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran

[3] Shiraz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Shiraz, Iran

[4] Shiraz Univ Med Sci, Gastroenterohepatol Res Ctr, Shiraz, Iran

[5] Shiraz Univ Med Sci, Ctr Cohort Study SUMS Employees Hlth, Shiraz, Iran

来源：

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS | 2022年 / 16卷 / 01期

关键词：

Whey protein; Inflammation; IL-6; TNF-alpha; Meta-analysis; BODY-COMPOSITION; DOUBLE-BLIND; DIETARY SUPPLEMENTATION; INFLAMMATORY MARKERS; BLOOD-PRESSURE; OVERWEIGHT; OBESITY; RISK; METABOLISM; RESISTANCE;

D O I：

10.1016/j.dsx.2021.102372

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: Due to inconsistent data about WP supplementation on inflammatory markers, present systematic review and meta-analysis was done to summarize its effect on TNF-alpha and IL-6. Methods: Our search was done in Pubmed, Scopus, Embase, and Cochrane up to June 2021. Weighted mean difference (WMD) and 95% confidence intervals (CI) was used to indicate the effect sizes. Conceivable sources of heterogeneity were detected by subgroup analysis. Results: Overall, 11 eligible RCTs were included. The pooled results showed that WP supplementation had no significant effect on TNF-alpha and IL-6 status compare to those receiving carbohydrate and other types of proteins as placebo. Results from subgroup analysis based on health status, study duration, WP dosage and sex, expressed no favorable effect of WP on TNF-alpha and IL-6 levels. Conclusion: It can be concluded that whey supplementation had no favorable effects on inflammatory biomarkers including TNF-alpha and IL-6. (c) 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.

引用

页数：9

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