Neuromuscular and cardiac comorbidity determines survival in 140 patients with left ventricular hypertrabeculation/noncompaction

被引:34
作者
Stoellberger, Claudia [1 ]
Blazek, Gerhard [2 ]
Wegner, Christian [3 ]
Winkler-Dworak, Maria [3 ]
Finsterer, Josef
机构
[1] Krankenanstalt Rudolfstiftung Wien, Dept Med 2, A-1030 Vienna, Austria
[2] Hanusch Hosp, A-1140 Vienna, Austria
[3] Austrian Acad Sci, Vienna Inst Demog, A-1040 Vienna, Austria
关键词
Noncompaction; Cardiomyopathy; Echocardiography; Prognosis; Myopathy; FOLLOW-UP; NONCOMPACTION; ADULTS;
D O I
10.1016/j.ijcard.2010.02.049
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The prognosis of patients with left ventricular hypertrabeculation/noncompaction (LVHT) is controversial. We assessed cardiologic and neurologic predictors for mortality in LVHT patients and how many received implantable cardioverters/defibrillators(ICD) or cardiac resynchronization devices (CRT). Methods and results: Included were patients with LVHT diagnosed echocardiographically between June 1995 and May 2009. All patients underwent a baseline cardiologic examination, and were invited for a neurological investigation. During June 2009, the patients were contacted by telephone and their records were screened if they had received ICD or CRT. In 140 patients (29% females, mean age 53 +/- 16, range 14-94 years) LVHT was diagnosed. The neurologic investigation, carried out in 76%, disclosed a neuromuscular disorder of definite (n= 22) or unknown (n= 68) etiology or was normal (n= 16). During a follow-up of 4.5 years the mortality was 5.7%/year. Causes of death were heart failure(n= 11), pneumonia (n= 6), sudden cardiac death (n= 3), malignancy (n= 3), pulmonary embolism (n= 2), sepsis (n= 2), stroke (n= 2), hepatic failure (n= 1) or unknown (n= 6). Sixteen patients received devices (ICD n= 4, CRT n= 3, ICD plus CRT n= 9). Predictors for mortality were increased age (p= 0.0307), neuromuscular disorder of definite or unknown etiology (p= 0.0063), exertional dyspnea (p= 0.0018), edema (p= 0.0000), heart failure (p= 0.0002), ventricular ectopic beats (p= 0.0119), atrial fibrillation (p= 0.0000), low voltage (p= 0.0139), presence of one or more ECG abnormalities (p= 0.0420), left ventricular fractional shortening < 25% (p= 0.0046), extension of LVHT (p= 0.0063) and LVHT affecting the lateral wall (p= 0.0110). Conclusion: Mortality in LVHT is high and due to cardiac and neuromuscular comorbidity, why monitoring and therapy, including device therapy, should be improved. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:71 / 74
页数:4
相关论文
共 19 条
[1]  
ABRAHAM WT, 2008, AM J CARDIOL, V102
[2]   Clinical features of isolated ventricular noncompaction in adults long-term clinical course, echocardiographic properties, and predictors of left ventricular failure [J].
Aras, Dursun ;
Tufekcioglu, Omac ;
Ergun, Kumral ;
Ozeke, Ozcan ;
Yildiz, Ali ;
Topaloglu, Serkan ;
Deveci, Bulent ;
Sahin, Onur ;
Kisacik, Halil Lutfi ;
Korkmaz, Sule .
JOURNAL OF CARDIAC FAILURE, 2006, 12 (09) :726-733
[3]  
Bonow RO, 2008, J AM COLL CARDIOL, V52, pE1, DOI [10.1016/j.hrthm.2008.04.014, 10.1016/j.jacc.2008.05.007]
[4]   ISOLATED NONCOMPACTION OF LEFT-VENTRICULAR MYOCARDIUM - A STUDY OF 8 CASES [J].
CHIN, TK ;
PERLOFF, JK ;
WILLIAMS, RG ;
JUE, K ;
MOHRMANN, R .
CIRCULATION, 1990, 82 (02) :507-513
[5]   Ethical authorship and publishing [J].
Coats, Andrew J. S. .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 131 (02) :149-150
[6]  
FINSTERER J, 2009, INT J CARDIOL 0327
[7]   Stroke from paroxysmal atrial flutter or left ventricular hypertrabeculation/noncompaction, visible only on transesophageal echocardiography [J].
Finsterer, Josef ;
Stoellberger, Claudia .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 134 (02) :E56-E58
[8]   Heart rate variability in adult patients with isolated left ventricular noncompaction [J].
Kawasaki, T ;
Azuma, A ;
Taniguchi, T ;
Asada, S ;
Kamitani, T ;
Kawasaki, S ;
Matsubara, H ;
Sugihara, H .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2005, 99 (01) :147-150
[9]   Wide spectrum of presentation and variable outcomes of isolated left ventricular non-compaction [J].
Lofiego, C. ;
Biagini, E. ;
Pasquale, F. ;
Ferlito, M. ;
Rocchi, G. ;
Perugini, E. ;
Bacchi-Reggiani, L. ;
Boriani, G. ;
Leone, O. ;
Caliskan, K. ;
ten Cate, F. J. ;
Picchio, F. M. ;
Branzi, A. ;
Rapezzi, C. .
HEART, 2007, 93 (01) :65-71
[10]   Neuromuscular Diseases After Cardiac Transplantation [J].
Mateen, Farrah J. ;
van de Beek, Diederik ;
Kremers, Walter K. ;
Daly, Richard C. ;
Edwards, Brooks S. ;
McGregor, Christopher G. A. ;
Wijdicks, Eelco F. M. .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2009, 28 (03) :226-230