Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure

被引：13
作者：
Mesaros, Clementina [1 ,2 ,3 ]
Worth, Andrew J. [1 ,2 ,3 ]
Snyder, Nathaniel W. [2 ,5 ]
Christofidou-Solomidou, Melpo [1 ,2 ,4 ]
Vachani, Anil [1 ,2 ,4 ]
Albelda, Steven M. [1 ,2 ,4 ]
Blair, Ian A. [1 ,2 ,3 ]
机构：
[1] Univ Penn, Perelman Sch Med, Penn SRP Ctr, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Ctr Excellence Environm Toxicol, Philadelphia, PA 19104 USA
[3] Univ Penn, Perelman Sch Med, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA
[4] Drexel Univ, AJ Drexel Autism Inst, Philadelphia, PA 19104 USA
[5] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA
来源：
BIOANALYSIS | 2015年 / 7卷 / 09期
基金：
美国国家卫生研究院;
关键词：
EXHALED BREATH CONDENSATE; MEGAKARYOCYTE POTENTIATING FACTOR; HUMAN MESOTHELIAL CELLS; OXIDATIVE STRESS; PLEURAL MESOTHELIOMA; SOLUBLE MESOTHELIN; LUNG-CANCER; CHRYSOTILE ASBESTOS; MALIGNANT MESOTHELIOMA; BRONCHOALVEOLAR LAVAGE;
D O I：
10.4155/bio.15.53
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Asbestos exposure is known to cause lung cancer and mesothelioma and its health and economic impacts have been well documented. The exceptionally long latency periods of most asbestos-related diseases have hampered preventative and precautionary steps thus far. We aimed to summarize the state of knowledge on biomarkers of response to asbestos exposure. Asbestos is not present in human biological fluids; rather it is inhaled and trapped in lung tissue. Biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, are analyzed. Several classes of molecules have been studied and evaluated for their potential utility as biomarkers of asbestos exposure. These studies range from small molecule oxidative stress biomarkers to proteins involved in immune responses.
引用
收藏
页码：1157 / 1173
页数：17
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