The potential role of thymoquinone in preventing the cardiovascular complications of COVID-19

被引：9
作者：
Ahmad, Ajaz [1 ]
Raish, Mohammad [2 ]
Alkharfy, Khalid M. [1 ]
机构：
[1] King Saud Univ, Dept Clin Pharm, Coll Pharm, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
来源：
VASCULAR PHARMACOLOGY | 2021年 / 141卷
关键词：
COVID-19; SARS-CoV; Cardiovascular complications; ACE-2; Thymoquinone; OXIDATIVE STRESS; THERAPEUTIC TARGET; INHIBITOR T-20; ANGIOTENSIN; HYPERTENSION; CORONAVIRUS; RECEPTOR; HEART; RISK; OIL;
D O I：
10.1016/j.vph.2021.106899
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new virus strain detected in late 2019 and not previously described in humans is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes corona virus disease (COVID-19). While potential therapeutic approaches for COVID-19 are being investigated, significant initiatives are being made to create protective drugs and study various antiviral agents to cure the infection. However, an effective treatment strategy against COVID-19 is worrisome inadequate. The objective of the present manuscript is to discuss the potential role of thymoquinone (TQ) in preventing the cardiovascular complications of COVID-19, focusing on viral inhibition, antioxidant potential, vascular effect, and cardiac protection. The multifunctional properties of TQ could potentially synergize with the activity of current therapeutic interventions and offer a basis for managing COVID-19 disease more effectively. Even though the experimental evidence is positive, a translational application of TQ in COVID-19 is timely warranted.
引用
收藏
页数：5
相关论文
共 61 条
[1]  
Ahmad A, 2020, EUR REV MED PHARMACO, V24, P4030, DOI 10.26355/eurrev_202004_20873
[2]   Covid-19 and thymoquinone: Connecting the dots [J].
Ahmad, Ajaz ;
Rehman, Muneeb U. ;
Ahmad, Parvaiz ;
Alkharfy, Khalid M. .
PHYTOTHERAPY RESEARCH, 2020, 34 (11) :2786-2789
[3]   Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis [J].
Ahmad, Ajaz ;
Alkharfy, Khalid M. ;
Jan, Basit Latief ;
Ahad, Abdul ;
Ansari, Mushtaq Ahmad ;
Al-Jenoobi, Fahad I. ;
Raish, Mohammad .
EXPERIMENTAL LUNG RESEARCH, 2020, 46 (3-4) :53-63
[4]   Effects of Selected Bioactive Natural Products on the Vascular Endothelium [J].
Ahmad, Ajaz ;
Khan, Rao M. A. ;
Alkharfy, Khalid M. .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2013, 62 (02) :111-121
[5]  
Alkharfy K.M., 2014, US Patent, Patent No. [8,895,625, 8895625]
[6]   NITRIC OXIDE PATHWAY AS A POTENTIAL THERAPEUTIC TARGET IN COVID-19 [J].
Alkharfy, Khalid M. ;
Rehman, Muneeb U. ;
Ahmad, Ajaz .
FARMACIA, 2020, 68 (06) :966-969
[7]   Thymoquinone reduces mortality and suppresses early acute inflammatory markers of sepsis in a mouse model [J].
Alkharfy, Khalid M. ;
Ahmad, Ajaz ;
Jan, Basit L. ;
Raish, Mohammad .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 98 :801-805
[8]   Thymoquinone modulates nitric oxide production and improves organ dysfunction of sepsis [J].
Alkharfy, Khalid M. ;
Ahmad, Ajaz ;
Raish, Mohammad ;
Vanhoutte, Paul M. .
LIFE SCIENCES, 2015, 143 :131-138
[9]   Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats [J].
Atta, Mustafa S. ;
El-Far, Ali H. ;
Farrag, Foad A. ;
Abdel-Diam, Mohamed M. ;
Al Jaouni, Soad K. ;
Mousa, Shaker A. .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
[10]   Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers [J].
Bavishi, Chirag ;
Maddox, Thomas M. ;
Messerli, Franz H. .
JAMA CARDIOLOGY, 2020, 5 (07) :745-747
1234567