Pretreatment with 5-hydroxymethyl-2-furaldehyde blocks scopolamine-induced learning deficit in contextual and spatial memory in male mice

被引:11
作者
Lee, Younghwan [1 ,4 ]
Gao, Qingtao [1 ,4 ]
Kim, Eunji [1 ,4 ]
Lee, Younghwa [1 ,4 ]
Park, Se Jin [1 ,4 ]
Lee, Hyung Eun [1 ,4 ]
Jang, Dae Sik [1 ,3 ,4 ]
Ryu, Jong Hoon [1 ,2 ,4 ]
机构
[1] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea
[2] Kyung Hee Univ, Dept Oriental Pharmaceut Sci, Seoul 130701, South Korea
[3] Kyung Hee Univ, Dept Pharmaceut Sci, Seoul 130701, South Korea
[4] Kyung Hee Univ, Kyung Hee East West Pharmaceut Res Inst, Coll Pharm, Seoul 130701, South Korea
关键词
5-Hydroxymethyl-2-furaldehyde; 5-HMF; Cognitive impairment; Learning and memory; Alzheimer's disease; LONG-TERM POTENTIATION; RED-BLOOD-CELLS; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; CHOLINERGIC BLOCKADE; MAPK CASCADE; WATER-MAZE; IMPAIRMENT; NMDA; GLUTAMATE;
D O I
10.1016/j.pbb.2015.04.007
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
5-Hydroxymethyl-2-furaldehyde (5-HMF) is a compound derived from the dehydration of certain sugars. The aim of the present study was to evaluate the effect of 5-HMF on the cognitive impairment induced by scopolamine, a muscarinic receptor antagonist. To measure various cognitive functions, we conducted the step-through passive avoidance task, the Y-maze task and the Morris water maze task. A single administration of 5-HMF (5 or 10 mg/kg, p.o.) significantly attenuates scopolamine-induced cognitive impairment in these behavioral tasks without changes in locomotor activity, and the effect of 5-HMF on scopolamine-induced cognitive impairment was significantly reversed by a sub-effective dose of MK-801, an NMDA-receptor antagonist. In addition, a single administration of 5-HMF (10 mg/kg, p.o.) enhanced the cognitive performance of normal naive mice in the passive avoidance task. Furthermore, Western blot analysis revealed that the levels of phosphorylated Ca2+/calmodulin-dependent protein kinase II-alpha (CaMKII) and extracellular signal-regulated kinases (ERK) were significantly enhanced by the single administration of 5-HMF in the hippocampal tissues. Taken together, the present study suggests that 5-HMF may block scopolamine-induced learning deficit and enhance cognitive function via the activation of NMDA receptor signaling, including CaMKII and ERK, and would be an effective candidate against cognitive disorders, such as Alzheimer's disease. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:57 / 64
页数:8
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