Interleukin-18: Perspectives on the newest interleukin

被引：66
作者：
Gillespie, MT
Horwood, NJ
机构：
[1] St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia
[2] Univ Melbourne, St Vincents Hosp, Dept Med, Fitzroy, Vic 3065, Australia
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 1998年 / 9卷 / 02期
关键词：
cytokines; IGI; IL-18; interferon gamma; T-cells;
D O I：
10.1016/S1359-6101(98)00004-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been identified. Recently the receptor for IL-18 was also characterised. Due to the structural and biological properties shared between IL-18 and IL-1 and their respective receptors, questions relating to IL-18 activities are being answered at a rapid pace. This article addresses the biology of IL-18 in both disease and non-disease states. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：109 / 116
页数：8
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