Radioprotective effect of self-assembled low molecular weight Fucoidan-Chitosan nanoparticles

被引：19

作者：

Wu, Szu-Yuan ^{[1
,2
,3
,4
,9
,10
]}

Parasuraman, Vijayarohini ^{[5
]}

Hsieh-Chih-Tsai ^{[5
,6
]}

Arunagiri, Vinothini ^{[5
]}

Gunaseelan, Srithar ^{[5
]}

Chou, Hsiao-Ying ^{[5
]}

Anbazhagan, Rajeshkumar ^{[5
,6
]}

Lai, Juin-Yih ^{[5
,6
,7
]}

Prasad, Rajendra N. ^{[8
]}

机构：

[1] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Coll Med & Hlth Sci, Taichung, Taiwan

[2] Lotung Poh Ai Hosp, Lo Hsu Med Fdn, Dept Med, Div Radiat Oncol, Yilan, Taiwan

[3] Taipei Med Univ, Sch Med, Dept Internal Med, Coll Med, Taipei, Taiwan

[4] Taipei Med Univ, Sch Med, Dept Radiol, Coll Med, Taipei, Taiwan

[5] Natl Taiwan Univ Sci & Technol, Grad Inst Appl Sci & Technol, Taipei, Taiwan

[6] Natl Taiwan Univ Sci & Technol, Adv Membrane Mat Ctr, Taipei, Taiwan

[7] Chung Yuan Christian Univ, R&D Ctr Membrane Technol, Taoyuan, Taiwan

[8] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India

[9] Lotung Poh Ai Hosp, Lo Hsu Med Fdn, Big Data Ctr, Yilan, Taiwan

[10] Asia Univ, Dept Healthcare Adm, Coll Med & Hlth Sci, Taichung, Taiwan

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2020年 / 579卷

关键词：

Oligofucoidan; Chitosan; Self-assembled; Nanoparticles; Radioprotection; SULFATED POLYSACCHARIDE; ANTIOXIDANT ACTIVITY; DELIVERY; TRANSPORT; ASSAY; SIZE;

D O I：

10.1016/j.ijpharm.2020.119161

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Fucoidan, a sulphated polysaccharide, plays a vital role in reducing cellular oxidative damage by exerting potential antioxidant activity. However, because of the negative surface charges of oligofucoidan, it shows poor oral intestinal absorption. To overcome this drawback, the oligofucoidan polysaccharides self-assembled with opposite charge based polysaccharides (chitosan) to form the chitosan-fucoidan polysaccharides (C-1-F3P) nanoparticles (NPs) of 190-230 nm in size. The oligofucoidan and C-1-F3P NPs were studied for their radioprotective property using mice exposed to 5 Gy radiation. The C-1-F3P NPs prevents radiation induced lipid peroxidation and restores intestinal enzymatic and non-enzymatic antioxidants (p < 0.05) status. In addition, hematoxylin-eosin staining revealed the radioprotective effect of oligofucoidan and C-1-F3P NPs by mitigating the loss of crypt and villi in the small intestine. Thus, the present study demonstrated that C-1-F3P NPs can be considered as a radioprotective agent that can be used for the prevention and treatment of Gy-radiation-induced intestine injury.

引用

页数：8

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