Liquid biopsy: state of reproductive medicine and beyond

被引：13
作者：
Schobers, Gaby [1 ,2 ]
Koeck, Rebekka [1 ,3 ]
Pellaers, Dominique [1 ,3 ]
Stevens, Servi J. C. [1 ]
Macville, Merryn V. E. [1 ]
Paulussen, Aimee D. C. [1 ,3 ]
Coonen, Edith [1 ,4 ]
van den Wijngaard, Arthur [1 ]
de Die-Smulders, Christine [1 ,3 ]
de Wert, Guido [5 ]
Brunner, Han G. [1 ,2 ,3 ]
Esteki, Masoud Zamani [1 ,3 ]
机构：
[1] Maastricht Univ Med Ctr, Dept Clin Genet, Maastricht, Netherlands
[2] Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands
[3] Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Genet & Cell Biol, Maastricht, Netherlands
[4] Maastricht Univ, Med Ctr, Ctr Reprod Med, Grow Sch Oncol & Dev Biol, Maastricht, Netherlands
[5] Maastricht Univ, Fac Hlth Med & Life Sci, GROW Sch Oncol & Dev Biol, Dept Hlth Eth & Soc, Maastricht, Netherlands
来源：
HUMAN REPRODUCTION | 2021年 / 36卷 / 11期
基金：
欧盟地平线“2020”;
关键词：
liquid biopsy; circulating cells; cell-free DNA; ART; IVF; spent embryo culture medium; non-invasive prenatal testing; preimplantation genetic testing; next generation sequencing; artificial intelligence; CELL-FREE DNA; CIRCULATING TUMOR-CELLS; EMBRYO CULTURE-MEDIUM; NONINVASIVE PRENATAL-DIAGNOSIS; FREE FETAL DNA; MATERNAL PLASMA; MITOCHONDRIAL-DNA; INCIDENTAL DETECTION; GENE-EXPRESSION; GENOMIC DNA;
D O I：
10.1093/humrep/deab206
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Y Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Furthermore, we emphasize the importance of artificial intelligence in analyzing liquid biopsy data with the aim of developing ethically-responsible non-invasive technologies that can enhance individualized healthcare. While previous reviews have mainly focused on cancer, this review primarily highlights applications of liquid biopsy in reproductive medicine.
引用
收藏
页码：2824 / 2839
页数：16
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