CBr4-photoirradiation protocol for chemoselective deprotection of acid labile primary hydroxyl protecting groups

被引：14

作者：

Chen, MY

Patkar, LN

Jan, MD

Lee, ASY

Lin, CC ^{[1
]}

机构：

[1] Acad Sinica, Inst Chem, Taipei 115, Taiwan

[2] Taipei Nursing Coll, Dept Gen Educ, Taipei 112, Taiwan

[3] Tamkang Univ, Dept Chem, Tamsui 251, Taiwan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 03期

关键词：

D O I：

10.1016/j.tetlet.2003.10.205

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CBr4-photoirradiation protocol was found to be a mild, highly efficient and selective method for deprotection of isopropylidene, benzylidene, triphenylmethyl and tert-butyldimethylsilyl protecting groups on sugar molecules. The conditions of this reaction can also be used to cleave peptides off from acid-labile resin linkers in solid-phase peptide synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：635 / 639

页数：5

共 18 条

[1]

Barone G, 2002, SYNLETT, P1645

[2]

Chan W., 1999, Fmoc solid phase peptide synthesis: a practical approach

[3]

CHAUDHARY SK, 1979, TETRAHEDRON LETT, V2, P95

[4] An efficient and highly selective deprotecting method for β-(trimethylsilyl)ethoxymethyl ethers [J].