Plasma Neutralization of the SARS-CoV-2 Omicron Variant

被引：310

作者：

Schmidt, Fabian ^{[1
]}

Muecksch, Frauke ^{[1
]}

Weisblum, Yiska ^{[1
]}

Da Silva, Justin ^{[1
]}

Bednarski, Eva ^{[1
]}

Cho, Alice ^{[1
]}

Wang, Zijun ^{[1
]}

Gaebler, Christian ^{[1
]}

Caskey, Marina ^{[1
]}

Nussenzweig, Michel C. ^{[1
]}

Hatziioannou, Theodora ^{[1
]}

Bieniasz, Paul D. ^{[1
]}

机构：

[1] Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2022年 / 386卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1056/NEJMc2119641

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Omicron Neutralization after the Third Vaccine Dose Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over time showed much lower omicron neutralization than Wuhan-hu-1 neutralization after two doses of an mRNA vaccine. However, samples from persons vaccinated after recovery from Covid-19 and those who received a booster vaccine had high levels of omicron neutralization.

引用

页码：599 / 601

页数：4

共 5 条

[1]

Gaebler C, 2021, NATURE, V591, P639, DOI [10.1101/2020.11.03.367391, 10.1038/s41586-021-03207-w]

[2] Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic [J].

Karim, Salim S. Abdool ;

Karim, Quarraisha Abdool .

LANCET, 2021, 398 (10317) :2126-+

[3]

Robbiani Davide F, 2020, bioRxiv, DOI [10.1038/s41586-020-2456-9, 10.1101/2020.05.13.092619]

[4] High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape [J].

Schmidt, Fabian ;

Weisblum, Yiska ;

Rutkowska, Magdalena ;

Poston, Daniel ;

DaSilva, Justin ;

Zhang, Fengwen ;

Bednarski, Eva ;

Cho, Alice ;

Schaefer-Babajew, Dennis J. ;

Gaebler, Christian ;

Caskey, Marina ;

Nussenzweig, Michel C. ;

Hatziioannou, Theodora ;

Bieniasz, Paul D. .

NATURE, 2021, 600 (7889) :512-+

[5] Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection [J].

Wang, Zijun ;

Muecksch, Frauke ;

Schaefer-Babajew, Dennis ;

Finkin, Shlomo ;

Viant, Charlotte ;

Gaebler, Christian ;

Hoffmann, Hans- Heinrich ;

Barnes, Christopher O. ;

Cipolla, Melissa ;

Ramos, Victor ;

Oliveira, Thiago Y. ;

Cho, Alice ;

Schmidt, Fabian ;

Da Silva, Justin ;

Bednarski, Eva ;

Aguado, Lauren ;

Yee, Jim ;

Daga, Mridushi ;

Turroja, Martina ;

Millard, Katrina G. ;

Jankovic, Mila ;

Gazumyan, Anna ;

Zhao, Zhen ;

Rice, Charles M. ;

Bieniasz, Paul D. ;

Caskey, Marina ;

Hatziioannou, Theodora ;

Nussenzweig, Michel C. .

NATURE, 2021, 595 (7867) :426-+

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