Cl-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)

被引:212
作者
Allen, LF
Sebolt-Leopold, J
Meyer, MB
机构
[1] Pfizer Global Res & Dev, Dept Clin Dev, Ann Arbor Labs, Ann Arbor, MI 48105 USA
[2] Pfizer Global Res & Dev, Dept Oncol, Ann Arbor Labs, Ann Arbor, MI 48105 USA
[3] Dept Canc Mol Sci, Ann Arbor, MI USA
关键词
D O I
10.1053/j.seminoncol.2003.08.012
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:105 / 116
页数:12
相关论文
共 100 条
[81]  
Schaeffer HJ, 1999, MOL CELL BIOL, V19, P2435
[82]   Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo [J].
Sebolt-Leopold, JS ;
Dudley, DT ;
Herrera, R ;
Van Becelaere, K ;
Wiland, A ;
Gowan, RC ;
Tecle, H ;
Barrett, SD ;
Bridges, A ;
Przybranowski, S ;
Leopold, WR ;
Saltiel, AR .
NATURE MEDICINE, 1999, 5 (07) :810-816
[83]   Development of anticancer drugs targeting the MAP kinase pathway [J].
Sebolt-Leopold, JS .
ONCOGENE, 2000, 19 (56) :6594-6599
[84]   PROTEIN KINASES .7. THE MAPK SIGNALING CASCADE [J].
SEGER, R ;
KREBS, EG .
FASEB JOURNAL, 1995, 9 (09) :726-735
[85]  
SEGER R, 1992, J BIOL CHEM, V267, P14373
[86]   Hyperexpression of mitogen-activated protein kinase in human breast cancer [J].
Sivaraman, VS ;
Wang, HY ;
Nuovo, GJ ;
Malbon, CC .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (07) :1478-1483
[87]  
Spencer VA, 2000, J CELL BIOCHEM, P27
[88]  
Strumberg D, 2002, Int J Clin Pharmacol Ther, V40, P580
[89]   Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells [J].
Timms, JF ;
White, SL ;
O'Hare, MJ ;
Waterfield, MD .
ONCOGENE, 2002, 21 (43) :6573-6586
[90]   Ras activation in human breast cancer [J].
von Lintig, FC ;
Dreilinger, AD ;
Varki, NM ;
Wallace, AM ;
Casteel, DE ;
Boss, GR .
BREAST CANCER RESEARCH AND TREATMENT, 2000, 62 (01) :51-62