Cl-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)

被引:211
作者
Allen, LF
Sebolt-Leopold, J
Meyer, MB
机构
[1] Pfizer Global Res & Dev, Dept Clin Dev, Ann Arbor Labs, Ann Arbor, MI 48105 USA
[2] Pfizer Global Res & Dev, Dept Oncol, Ann Arbor Labs, Ann Arbor, MI 48105 USA
[3] Dept Canc Mol Sci, Ann Arbor, MI USA
关键词
D O I
10.1053/j.seminoncol.2003.08.012
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:105 / 116
页数:12
相关论文
共 100 条
[1]   PHORBOL ESTER STIMULATES A PROTEIN-TYROSINE THREONINE KINASE THAT PHOSPHORYLATES AND ACTIVATES THE ERK-1 GENE-PRODUCT [J].
ALESSANDRINI, A ;
CREWS, CM ;
ERIKSON, RL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (17) :8200-8204
[2]   PD-098059 IS A SPECIFIC INHIBITOR OF THE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN-VITRO AND IN-VIVO [J].
ALESSI, DR ;
CUENDA, A ;
COHEN, P ;
DUDLEY, DT ;
SALTIEL, AR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) :27489-27494
[3]   Mitogen-activated protein kinases [J].
Arbabi, S ;
Maier, RV .
CRITICAL CARE MEDICINE, 2002, 30 (01) :S74-S79
[4]   p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis [J].
Assefa, Z ;
Vantieghem, A ;
Garmyn, M ;
Declercq, W ;
Vandenabeele, P ;
Vandenheede, JR ;
Bouillon, R ;
Merlevede, W ;
Agostinis, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (28) :21416-21421
[5]   RAF MEETS RAS - COMPLETING THE FRAMEWORK OF A SIGNAL-TRANSDUCTION PATHWAY [J].
AVRUCH, J ;
ZHANG, XF ;
KYRIAKIS, JM .
TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (07) :279-283
[6]   HIERARCHY OF BINDING-SITES FOR GRB2 AND SHC ON THE EPIDERMAL GROWTH-FACTOR RECEPTOR [J].
BATZER, AG ;
ROTIN, D ;
URENA, JM ;
SKOLNIK, EY ;
SCHLESSINGER, J .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (08) :5192-5201
[7]   DIVERSITY IN FUNCTION AND REGULATION OF MAP KINASE PATHWAYS [J].
BLUMER, KJ ;
JOHNSON, GL .
TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (06) :236-240
[8]   ERKS - A FAMILY OF PROTEIN-SERINE THREONINE KINASES THAT ARE ACTIVATED AND TYROSINE PHOSPHORYLATED IN RESPONSE TO INSULIN AND NGF [J].
BOULTON, TG ;
NYE, SH ;
ROBBINS, DJ ;
IP, NY ;
RADZIEJEWSKA, E ;
MORGENBESSER, SD ;
DEPINHO, RA ;
PANAYOTATOS, N ;
COBB, MH ;
YANCOPOULOS, GD .
CELL, 1991, 65 (04) :663-675
[9]  
BROTT BK, 1996, CELL GROWTH DIFFER, V4, P921
[10]  
Bucci B, 1997, ANTICANCER RES, V17, P769