Background: Due to uncertainly of chronic headache status as a society health problem, this study was conducted to determine total prevalence of headache and related factors. Methods: In Tabari cohort study (TCS), a variety of demographic and clinical data were collected from individuals aged between 35 and 70 years using a standard questionnaire. The prevalence of chronic headache and the duration of the outcome were obtained through self-reported information. In statistical analysis, Chi-square and multivariate logistic regression tests were used to evaluate the association between outcome and risk factors. Results: 10255 adults living in Mazandaran, Sari, 4149 women and 6106 male, were included in this study. The total prevalence of chronic headache was 13% (12.3%-13.6%). Factors such as female gender (OR: 4.10; 95% CI: 3.41-4.93), mountainous residence (OR: 1.26; 95% CI: 1.07-1.49), depression (OR: 1.73; 95% CI: 1.44-2.08), back pain (OR: 1.54; 95% CI: 1.36-1.74), history of head trauma (OR: 1.85; 95% CI: 1.44-2.37) and blood pressure (OR: 1.43; 95% CI: 1.24-1.65) significantly increases the odds of chronic headache. Conclusion: The prevalence of chronic headaches in the Mazandaran province is more than. Other parts of the world, and this region needs special attention. A significant proportion of the adolescent population, especially women, suffer from chronic headaches in the cohort of Tabari, which is affected by factors such as location, back pain and depression.