Glutathione, glutathione-related enzymes, and oxidative stress in individuals with subacute occupational exposure to lead

被引：27

作者：

Dobrakowski, Michal ^{[1
]}

Pawlas, Natalia ^{[2
]}

Hudziec, Edyta ^{[1
]}

Kozlowska, Agnieszka

Mikolajczyk, Agnieszka ^{[2
]}

Birkner, Ewa ^{[1
]}

Kasperczyk, Slawornir ^{[1
]}

机构：

[1] Med Univ Silesia, Div Dent, Sch Med, Dept Biochem, Ul Jordana 19, PL-41808 Zabrze, Poland

[2] Inst Occupat Med & Environm Hlth Sosnowiec, Ul Koscielna 13, PL-41200 Sosnowiec, Poland

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2016年 / 45卷

关键词：

Subacute exposure to lead; Glutathione; Oxidative stress; DNA damage; Lipid peroxidation; ANTIOXIDANT ENZYMES; DNA-DAMAGE; WORKERS; BLOOD; ERYTHROCYTES; PEROXIDASE; PARAMETERS; EXPRESSION; REDUCTASE; CELLS;

D O I：

10.1016/j.etap.2016.06.008

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The aim of the study was to investigate the influence of subacute exposure to lead on the glutathione-related antioxidant defense and oxidative stress parameters in 36 males occupationally exposed to lead for 40 +/- 3.2 days. Blood lead level in the examined population increased significantly by 359% due to lead exposure. Simultaneously, erythrocyte glutathione level decreased by 16%, whereas the activity of glutathione6-phosphate dehydrogenase in erythrocytes and leukocytes decreased by 28% and 10%, respectively. Similarly, the activity of glutathione-S-transferase in erythrocytes decreased by 45%. However, the activity of glutathione reductase in erythrocytes and leukocytes increased by 26% and 6%, respectively, whereas the total oxidant status value in leukocytes increased by 37%. Subacute exposure to lead results in glutathione pool depletion and accumulation of lipid peroxidation products; however, it does not cause DNA damage. Besides, subacute exposure to lead modifies the activity of glutathione-related enzymes. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：235 / 240

页数：6

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