What a gastrointestinal biopsy can tell us about Parkinson's disease?

被引：27
作者：
Corbille, A. -G. [1 ,2 ,3 ]
Clairembault, T. [1 ,2 ]
Coron, E. [1 ,2 ,4 ]
Leclair-Visonneau, L. [1 ,2 ]
Preterre, C. [1 ,3 ]
Neunlist, M. [1 ,2 ,4 ]
Derkinderen, P. [1 ,2 ,3 ]
机构：
[1] INSERM, U913, 1 Pl Alexis Ricordeau, F-44035 Nantes, France
[2] Univ Nantes, Nantes, France
[3] CHU Nantes, Dept Neurol, Nantes, France
[4] CHU Nantes, Inst Malad Appareil Digestif, Nantes, France
来源：
NEUROGASTROENTEROLOGY AND MOTILITY | 2016年 / 28卷 / 07期
关键词：
enteric glial cells; enteric nervous system; enteric neurons; gastrointestinal biopsy; Parkinson's disease; ENTERIC NERVOUS-SYSTEM; ALPHA-SYNUCLEIN PATHOLOGY; INTESTINAL EPITHELIAL BARRIER; FIBRILLARY ACIDIC PROTEIN; DETECT LEWY PATHOLOGY; GLIAL-CELLS; COLONIC BIOPSIES; CEREBROSPINAL-FLUID; GUINEA-PIG; PERMEABILITY;
D O I：
10.1111/nmo.12797
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background The intraneuronal inclusions called Lewy bodies and neurites, which represent the characteristic pathological changes in Parkinson's disease, are found in the enteric neurons in the great majority of parkinsonian patients. This observation led to a substantial amount of research over the last few years in order to develop a minimally invasive diagnostic procedure in living patients based on gastrointestinal (GI) biopsies. Purpose In this review, we will begin by discussing the studies that focused on the detection of Lewy bodies and neurites in GI biopsies, then broaden the discussion to the pathological changes that also occur in the enteric glial cells and intestinal epithelial cells. We conclude by proposing that a GI biopsy could represent a unique window to assess the whole pathological process of the brain in Parkinson's disease.
引用
收藏
页码：966 / 974
页数：9
相关论文
共 75 条
  • [1] Submandibular gland needle biopsy for the diagnosis of Parkinson disease
    Adler, Charles H.
    Dugger, Brittany N.
    Hinni, Michael L.
    Lott, David G.
    Driver-Dunckley, Erika
    Hidalgo, Jose
    Henry-Watson, Jonette
    Serrano, Geidy
    Sue, Lucia I.
    Nagel, Thomas
    Duffy, Amy
    Shill, Holly A.
    Akiyama, Haruhiko
    Walker, Douglas G.
    Beach, Thomas G.
    [J]. NEUROLOGY, 2014, 82 (10) : 858 - 864
  • [2] Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss
    Annerino, Dana M.
    Arshad, Shawn
    Taylor, Georgia M.
    Adler, Charles H.
    Beach, Thomas G.
    Greene, James G.
    [J]. ACTA NEUROPATHOLOGICA, 2012, 124 (05) : 665 - 680
  • [3] Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption
    Aubé, AC
    Cabarrocas, J
    Bauer, J
    Philippe, D
    Aubert, P
    Doulay, F
    Liblau, R
    Galmiche, JP
    Neunlist, M
    [J]. GUT, 2006, 55 (05) : 630 - 637
  • [4] Evaluation of α-synuclein immunohistochemical methods used by invited experts
    Beach, Thomas G.
    White, Charles L.
    Hamilton, Ronald L.
    Duda, John E.
    Iwatsubo, Takeshi
    Dickson, Dennis W.
    Leverenz, James B.
    Roncaroli, Federico
    Buttini, Manuel
    Hladik, Christa L.
    Sue, Lucia I.
    Noorigian, Joseph V.
    Adler, Charles H.
    [J]. ACTA NEUROPATHOLOGICA, 2008, 116 (03) : 277 - 288
  • [5] Submandibular Gland Biopsy for the Diagnosis of Parkinson Disease
    Beach, Thomas G.
    Adler, Charles H.
    Dugger, Brittany N.
    Serrano, Geidy
    Hidalgo, Jose
    Henry-Watson, Jonette
    Shill, Holly A.
    Sue, Lucia I.
    Sabbagh, Marwan N.
    Akiyama, Haruhiko
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2013, 72 (02) : 130 - 136
  • [6] Beach TG, 2009, ACTA NEUROPATHOL, V117, P613, DOI [10.1007/s00401-009-0538-8, 10.1007/s00401-010-0664-3]
  • [7] Enteric nervous system - Functional organization and neurologic implications
    Benarroch, Eduardo E.
    [J]. NEUROLOGY, 2007, 69 (20) : 1953 - 1957
  • [8] α-Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
    Bloch, A
    Probst, A
    Bissig, H
    Adams, H
    Tolnay, M
    [J]. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2006, 32 (03) : 284 - 295
  • [9] Heterogeneity and Phenotypic Plasticity of Glial Cells in the Mammalian Enteric Nervous System
    Boesmans, Werend
    Lasrado, Reena
    Vanden Berghe, Pieter
    Pachnis, Vassilis
    [J]. GLIA, 2015, 63 (02) : 229 - 241
  • [10] Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    Braak, H
    de Vos, RAI
    Bohl, J
    Del Tredici, K
    [J]. NEUROSCIENCE LETTERS, 2006, 396 (01) : 67 - 72
12345678