MiR-101-3p Suppresses Progression of Cervical Squamous Cell Carcinoma by Targeting and Down-Regulating KPNA2

被引：8
作者：
Wang, Hong [1 ]
Xiao, Rongxin [1 ]
Yang, Biao [1 ]
机构：
[1] Funing Peoples Hosp, Funing, Jiangsu, Peoples R China
来源：
TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2021年 / 20卷
关键词：
microRNA-101-3p; KPNA2; cervical squamous cell carcinoma; proliferation; migration; invasion; CANCER; PROLIFERATION; ALPHA-2;
D O I：
10.1177/15330338211055948
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective We explored mechanism of microRNA-101-3p/Karyopherin alpha 2 (KPNA2) axis in cervical squamous cell carcinoma. Methods: Bioinformatics methods were applied to identify genes for the study. Cell functional assays were implemented to examine the role of the genes in malignant progression of cervical squamous cell carcinoma. Targeting relationship between genes was verified by dual-luciferase assay. Results: MicroRNA-101-3p was lowly expressed in cervical squamous cell carcinoma, while KPNA2 was highly expressed. Dual-luciferase assay identified direct targeting relationship between microRNA-101-3p and KPNA2. Functional assays manifested that highly expressed microRNA-101-3p suppressed cervical squamous cell carcinoma cell growth by targeting KPNA2. Conclusion: Overall, microRNA-101-3p/KPNA2 axis can play an important part in progression of cervical squamous cell carcinoma.
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页数：7
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共 20 条
  • [1] Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin α2 as a potential novel prognostic marker in breast cancer
    Dahl, Edgar
    Kristiansen, Glen
    Gottlob, Kathrin
    Klaman, Irina
    Ebner, Elke
    Hinzmann, Bernd
    Hermann, Klaus
    Pilarsky, Christian
    Duerst, Matthias
    Klinkhammer-Schalke, Monika
    Blaszyk, Hagen
    Knuechel, Ruth
    Hartmann, Arndt
    Rosenthal, Andre
    Wild, Peter J.
    [J]. CLINICAL CANCER RESEARCH, 2006, 12 (13) : 3950 - 3960
  • [2] Prognostic value of C-reactive protein/albumin ratio in predicting overall survival of Chinese cervical cancer patients overall survival: comparison among various inflammation based factors
    He, Xia
    Li, Jian-Pei
    Liu, Xiao-Hua
    Zhang, Jing-Ping
    Zeng, Qiu-Yao
    Chen, Hao
    Chen, Shu-Lin
    [J]. JOURNAL OF CANCER, 2018, 9 (10): : 1877 - 1884
  • [3] Use of mesothelin as a tumor-associated antigen in cervical squamous cell carcinoma
    He, Yue
    Zhao, Hui
    Li, Xing-Ming
    Yin, Cheng-Hong
    Wu, Yu-Mei
    [J]. GENE, 2019, 690 : 30 - 37
  • [4] KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a
    Huang, L.
    Wang, H-Y
    Li, J-D
    Wang, J-H
    Zhou, Y.
    Luo, R-Z
    Yun, J-P
    Zhang, Y.
    Jia, W-H
    Zheng, M.
    [J]. CELL DEATH & DISEASE, 2013, 4 : e745 - e745
  • [5] Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.21492, 10.3322/caac.20115, 10.3322/caac.20107]
  • [6] Comparison between adjuvant chemotherapy and adjuvant radiotherapy/chemoradiotherapy after radical surgery in patients with cervical cancer: a meta-analysis
    Lee, Kwang-Beom
    Shim, Seung-Hyuk
    Lee, Jong-Min
    [J]. JOURNAL OF GYNECOLOGIC ONCOLOGY, 2018, 29 (04)
  • [7] LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression
    Liang, Haihai
    Yu, Tong
    Han, Yue
    Jiang, Hua
    Wang, Chengyu
    You, Tianyi
    Zhao, Xiaoguang
    Shan, Huitong
    Yang, Rui
    Yang, Lida
    Shan, Hongli
    Gu, Yunyan
    [J]. MOLECULAR CANCER, 2018, 17
  • [8] MiR-26b/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4
    Lin, Jiaxin
    Zhang, Lan
    Huang, He
    Huang, Yongwen
    Huang, Long
    Wang, Jianhua
    Huang, Shuting
    He, Li
    Zhou, Yun
    Jia, Weihua
    Yun, Jingping
    Luo, Rongzhen
    Zheng, Min
    [J]. ONCOTARGET, 2015, 6 (27) : 23793 - 23806
  • [9] mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK
    Liu, Peng
    Ye, Feng
    Xie, Xinhua
    Li, Xing
    Tang, Hailin
    Li, Shuaijie
    Huang, Xiaojia
    Song, Cailu
    Wei, Weidong
    Xie, Xiaoming
    [J]. ONCOTARGET, 2016, 7 (23) : 35188 - 35198
  • [10] Prognostic implications of decreased microRNA-101-3p expression in patients with non-small cell lung cancer
    Lu, Hai-Min
    Yi, Wan-Wan
    Ma, Yu-Shui
    Wu, Wei
    Yu, Fei
    Fan, Heng-Wei
    Lv, Zhong-Wei
    Yang, Hui-Qiong
    Chang, Zheng-Yan
    Zhang, Chao
    Xie, Wen-Ting
    Jiang, Jun-Jian
    Song, Ying-Chun
    Chai, Li
    Jia, Cheng-You
    Lu, Gai-Xia
    Zhong, Xiao-Jun
    Hou, Li-Kun
    Wu, Chun-Yan
    Shi, Min-Xin
    Liu, Ji-Bin
    Fu, Da
    [J]. ONCOLOGY LETTERS, 2018, 16 (06) : 7048 - 7056
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