Delayed and bilateral changes of GAP-43/B-50 phosphorylation after circling training during a critical period in rat striatum

被引：3

作者：

Azcurra, JM ^{[1
]}

Soiza-Reilly, M ^{[1
]}

Fossati, M ^{[1
]}

Paratcha, GC ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Lab Biol Celular, Buenos Aires, DF, Argentina

来源：

MOLECULAR BRAIN RESEARCH | 2003年 / 118卷 / 1-2期

关键词：

striatum; development; plasticity; GAP-43/B-50; circling training; motor activity;

D O I：

10.1016/j.molbrainres.2003.08.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During the critical period of activity-dependent plasticity in rat striatum (30-37 days after birth) physiological circling behavior induces delayed modifications in GAP-43/B-50 phosphorylation by PKC. Postexercise, ipsi- and contralateral striatum to the circling direction show a similar temporal pattern of GAP-43/B-50 phosphorylation, with an initial decrease followed by a subsequent increase. However, there is a lag between initiation of the phosphorylation response in this asymmetrical task which does not occur when animals are subjected to exercise under conditions of symmetrical motor activity. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：166 / 170

页数：5

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