A liposome preparation based on β-CD-LPC molecule and its application as drug-delivery system

Aim: The beta-CD-LPC molecule was synthesized based on the conjugation of LPC and beta-CD molecules and it could self-assemble into liposome which was used to encapsulate the Dox to form nanomedicine for the cancer therapy. Materials & methods: The anticancer and antitumor effect of beta-CD-LPC-Dox nanomedicine was studied with the vitro and vivo experimental methods. Results: The result showed that beta-CD-LPC liposome had high Dox drug-loading rate and a good sustained-release effect. Cell experiment showed that the beta-CD-LPC-Dox nanomedicine could effectively induce cancer cell apoptosis and in vivo experiments showed that beta-CD-LPC-Dox liposome could effectively inhibit tumor growth and had an effective anticancer activity with lower biotoxicity. Conclusion: The beta-CD-LPC-Dox nanomedicine could be applied as a candidate drug to therapy the cancer.