Synthesis and biological activity of 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines

被引：0
作者：
Havaldar, Freddy H. [1 ]
Khatri, Navinchandra K. [1 ]
机构：
[1] St Xavier Coll, Dept Chem, NSR Lab, Bombay 400001, Maharashtra, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2007年 / 19卷 / 07期
关键词：
synthesis; pyrazolines; antibacterial; antifungal activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
3-Aminoacetophenone was diazotized and reacted with sodium cyanide to yield 3-cyano acetophenone (1). 3-Cyano acetophenone was treated with conc. sulphuric acid to obtain 3-carboxy acetophenone (2) which on condensation with various aromatic aldehydes in hydrotopes afforded substituted chalcones (3a-e). The chalcones (3a-e) on cyclization with hydrazine hydrate in glacial acetic acid furnished 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines (4a-e). The constitution of the products was supported by IR, NMR, Mass spectral data and elemental analysis. All the compounds synthesized have been screened for their biological activity.
引用
收藏
页码：5093 / 5097
页数：5
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