Synthesis and biological activity of 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines

被引：0

作者：

Havaldar, Freddy H. ^{[1
]}

Khatri, Navinchandra K. ^{[1
]}

机构：

[1] St Xavier Coll, Dept Chem, NSR Lab, Bombay 400001, Maharashtra, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2007年 / 19卷 / 07期

关键词：

synthesis; pyrazolines; antibacterial; antifungal activity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3-Aminoacetophenone was diazotized and reacted with sodium cyanide to yield 3-cyano acetophenone (1). 3-Cyano acetophenone was treated with conc. sulphuric acid to obtain 3-carboxy acetophenone (2) which on condensation with various aromatic aldehydes in hydrotopes afforded substituted chalcones (3a-e). The chalcones (3a-e) on cyclization with hydrazine hydrate in glacial acetic acid furnished 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines (4a-e). The constitution of the products was supported by IR, NMR, Mass spectral data and elemental analysis. All the compounds synthesized have been screened for their biological activity.

引用

页码：5093 / 5097

页数：5

共 50 条

[21] Synthesis and in-vitro-antibacterial activity of [5-(furan-2-yl)-phenyl]-4,5-carbothioamide-pyrazolines [J].

Rani, Mamta ;

Yusuf, Mohamad ;

Khan, Salman Ahmad .

JOURNAL OF SAUDI CHEMICAL SOCIETY, 2012, 16 (04) :431-436

[22] Synthesis and antimicrobial activity of 1-phenyl/substituted phenyl/benzyl/naphthyl-2-phenyl-4-(3′-phenoxy benzylidene)-imidazoline-5-ones [J].

Solankee, A ;

Kapadia, K ;

Patel, J ;

Thakor, I .

ASIAN JOURNAL OF CHEMISTRY, 2002, 14 (02) :699-702

[23] Synthesis and antimicrobial activity of some new 3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2-styrylquinazoline-4(3H)-ones [J].

Gupta, Vivek ;

Kashaw, Sushil K. ;

Jatav, Varsha ;

Mishra, Pradeep .

MEDICINAL CHEMISTRY RESEARCH, 2008, 17 (2-7) :205-211

[24] Synthesis and biological activity of some substituted 2-phenyl-quinazolin-4-ones [J].

Raghavendra, NM ;

Niranjan, MS ;

Venkatesh, P ;

Kumar, BR ;

Gowda, NB ;

Sripathi, MS .

ASIAN JOURNAL OF CHEMISTRY, 2005, 17 (01) :57-65

[25] Synthesis and Biological Activity of Novel 2-(Substituted-benzylthio)-5-(4,6-dimethylpyrimidin-2-thiomethyl)-1,3,4-oxadiazoles [J].

Wang, Zhouyang ;

Xu, Hanjing ;

Zhao, Jianping ;

Liu, Xinghai ;

Wang, Jianquan .

CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 38 (11) :3112-3117

[26] Synthesis and antimicrobial activity of 3-(3-[(4-chlorophenyl)-sulphonamido]phenyl}-5-aryl-Δ2-pyrazolines [J].

Jamode, VS ;

Bhagat, PR ;

Chandak, HS .

ASIAN JOURNAL OF CHEMISTRY, 2004, 16 (3-4) :1837-1841

[27] Synthesis, spectral studies and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines [J].

Abid, Mohammad ;

Bhat, Abdul Roouf ;

Athar, Fareeda ;

Azam, Amir .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (01) :417-425

[28] Design, Synthesis and Biological Activity of Novel (3-Substituted phenyl-2-propen-1-ylidene)-benzoylhydrazones [J].

Xu, Yan ;

Lei, Peng ;

Ling, Yun ;

Wang, Shengwen ;

Yang, Xinling .

CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2014, 34 (06) :1118-1123

[29] 1-N-substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazolines:: Synthesis and evaluation as MAO inhibitors [J].

Gökhan, N ;

Yesilada, A ;

Uçar, G ;

Erol, K ;

Bilgin, AA .

ARCHIV DER PHARMAZIE, 2003, 336 (08) :362-371

[30] Synthesis, antibacterial and antifungal activity of some novel 3-[5-(4-substituted phenyl) 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones [J].

Varsha Jatav ;

Sushil Kashaw ;

Pradeep Mishra .

Medicinal Chemistry Research, 2008, 17 :169-181

← 1 2 3 4 5 →