Synthesis and biological activity of 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines

被引：0

作者：

Havaldar, Freddy H. ^{[1
]}

Khatri, Navinchandra K. ^{[1
]}

机构：

[1] St Xavier Coll, Dept Chem, NSR Lab, Bombay 400001, Maharashtra, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2007年 / 19卷 / 07期

关键词：

synthesis; pyrazolines; antibacterial; antifungal activity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3-Aminoacetophenone was diazotized and reacted with sodium cyanide to yield 3-cyano acetophenone (1). 3-Cyano acetophenone was treated with conc. sulphuric acid to obtain 3-carboxy acetophenone (2) which on condensation with various aromatic aldehydes in hydrotopes afforded substituted chalcones (3a-e). The chalcones (3a-e) on cyclization with hydrazine hydrate in glacial acetic acid furnished 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines (4a-e). The constitution of the products was supported by IR, NMR, Mass spectral data and elemental analysis. All the compounds synthesized have been screened for their biological activity.

引用

页码：5093 / 5097

页数：5