Synthesis and biological activity of 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines

被引：0
|
作者：
Havaldar, Freddy H. [1 ]
Khatri, Navinchandra K. [1 ]
机构：
[1] St Xavier Coll, Dept Chem, NSR Lab, Bombay 400001, Maharashtra, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2007年 / 19卷 / 07期
关键词：
synthesis; pyrazolines; antibacterial; antifungal activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
3-Aminoacetophenone was diazotized and reacted with sodium cyanide to yield 3-cyano acetophenone (1). 3-Cyano acetophenone was treated with conc. sulphuric acid to obtain 3-carboxy acetophenone (2) which on condensation with various aromatic aldehydes in hydrotopes afforded substituted chalcones (3a-e). The chalcones (3a-e) on cyclization with hydrazine hydrate in glacial acetic acid furnished 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines (4a-e). The constitution of the products was supported by IR, NMR, Mass spectral data and elemental analysis. All the compounds synthesized have been screened for their biological activity.
引用
收藏
页码：5093 / 5097
页数：5
相关论文
共 50 条
  • [1] Synthesis of 3-[3-(4′-methyl-benzenesulfonamido)phenyl]-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines
    Havaldar, FH
    Khatri, NK
    ASIAN JOURNAL OF CHEMISTRY, 2005, 17 (02) : 1337 - 1339
  • [2] Synthesis of 3-(4"-substituted phenyl)-5-(4′-substituted phenyl)-Δ2-pyrazolines and their derivatives
    Deshmukh, AY
    Raghuwanshi, PB
    Doshi, AG
    ASIAN JOURNAL OF CHEMISTRY, 2002, 14 (01) : 185 - 189
  • [3] Synthesis of 5-(4-substituted phenyl)-2-phenyl oxazoles
    Kamat, V. D.
    Mandhare, P. N.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2008, 17 (04) : 369 - 370
  • [4] Synthesis, physicochemical characterization, and biological activity of nanocomplexes of iron(III) of 3(2′-hydroxyphenyl)-5-(4-substituted phenyl) pyrazolines and dithiophosphoric acid
    Tripathi, U. N.
    Siddiqui, A.
    Singh, Kajal
    Vishwakarma, Shikha
    Mishra, Praveen Kumar
    JOURNAL OF COORDINATION CHEMISTRY, 2014, 67 (07) : 1249 - 1264
  • [5] Synthesis and Antitubercular Activity of Some 2-(4-Substituted phenyl)-3-(4-substituted phenyl)-5-methylthiazolidin-4-ones
    Patil, Sunila T.
    Bhatt, Parloop A.
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (03) : 1405 - 1406
  • [6] 1-[3/-(SUBSTITUTED PHENYL) -5/- (AMINO PYRIMIDINE)]- 3- (4/-NITRO PHENYL) 5- (SUBSTITUTED PHENYL)- 2-PYRAZOLINES: SYNTHESIS, CHRACTERISATION AND ANTIMICROBIAL SCREENING
    Hatwar, Y. A.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2018, 9 (02): : 642 - 649
  • [7] Synthesis of some new 3-(substituted phenyl)-5-(9-anthryl)-2-pyrazolines, 1-phenyl-3-(substituted phenyl)-5-(9-anthryl)-2-pyrazolines and 2-(9-anthryl)-4-(substituted phenyl)-1,5-benzothiazepines as antibacterial agents
    Dawane, B. S.
    Vibhute, Y. B.
    Konda, S. G.
    Mali, M. R.
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (06) : 4199 - 4204
  • [8] Synthesis and antibacterial activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones
    Khalaj, A
    Adibpour, N
    Shahverdi, AR
    Daneshtalab, M
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (08) : 699 - 705
  • [9] Synthesis of 2-((4-Substituted Phenyl) Amino) Benzaldehyde
    Duan, Yongli
    Li, Zhimin
    Tang, Qidong
    Li, Rui
    Xu, Shan
    PROCEEDINGS OF THE 2016 7TH INTERNATIONAL CONFERENCE ON EDUCATION, MANAGEMENT, COMPUTER AND MEDICINE (EMCM 2016), 2017, 59 : 581 - 584
  • [10] Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates
    Kratky, Martin
    Bosze, Szilvia
    Baranyai, Zsuzsa
    Szabo, Ildiko
    Stolarikova, Jirina
    Paraskevopoulos, Georgios
    Vinsova, Jarmila
    BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (04) : 868 - 875
12345