Is vasohibin-1 for more than angiogenesis inhibition?

被引：18

作者：

Sato, Yasufumi ^{[1
]}

机构：

[1] Tohoku Univ, Dept Vasc Biol, Inst Dev Aging & Canc, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2011年 / 149卷 / 03期

关键词：

Angiogenesis; Bone Marrow; Endothelium; FeedbackHematopoiesis; EXPRESSION; ENDOTHELIUM;

D O I：

10.1093/jb/mvq152

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiogenesis, a formation of neo-vessels from pre-existing ones, is regulated by the local balance between its stimulators and inhibitors. Vasohibin-1 (VASH1) was originally identified as an endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor that acts in a negative feedback manner. The expression of VASH1 has been shown in endothelial cells (ECs) in both physiological and pathological conditions associated with angiogenesis. However, recent reports indicate that VASH1 is expressed not only in ECs but also in other cell types including haematopoietic cells. The function of VASH1 may not be restricted to angiogenesis inhibition.

引用

页码：229 / 230

页数：2

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