Plasmonic DNA: Towards genetic diagnosis chips

被引：21

作者：

Hottin, Jerome

Moreau, Julien

Roger, Gisele

Spadavecchia, Jolanda

Millot, Marie-Claude

Goossens, Michel

Canva, Michael ^{[1
]}

机构：

[1] Univ Paris Sud, Grad Sch, Inst Opt, Lab Charles Fabry Inst Opt,CNRS, F-91127 Palaiseau, France

[2] Univ Paris 12, UMR 7182, CNRS, Inst Chim Mat Paris Est,Equipe Syst Polymeres C, F-94320 Thiais, France

[3] Univ Paris 12, Fac Med, INSERM, Plate Forme Genom IFR10,Unite 841, F-94010 Creteil, France

来源：

PLASMONICS | 2007年 / 2卷 / 04期

关键词：

surface plasmon resonance imaging (SPRI); DNA sensor; DNA-DNA interactions; surface functionalization; mutation; genetic diagnosis;

D O I：

10.1007/s11468-007-9039-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The present paper summarizes some of our activities in the field of plasmonic DNA and genetic diagnosis, presenting our system and its capabilities before showing data related to the design and use of functionalized biochips of increasing complexity along with various experimental hybridization conditions, including solutions containing one type of purified synthetic short oligonucleotides or PCR-amplified DNA samples from patients. The diagnosis capability of our system was evaluated by detecting several point mutations that alter the function of the CFTR gene and cause cystic fibrosis, a frequent monogenic disorder selected as a clinical model system.

引用

页码：201 / 215

页数：15

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