Rethinking cancer nanotheranostics

被引:1029
作者
Chen, Hongmin [1 ,3 ]
Zhang, Weizhong [2 ]
Zhu, Guizhi [2 ]
Xie, Jin [2 ,3 ]
Chen, Xiaoyuan [4 ]
机构
[1] Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China
[2] Univ Georgia, Dept Chem, Athens, GA 30602 USA
[3] Univ Georgia, Bio Imaging Res Ctr, Athens, GA 30602 USA
[4] Natl Inst Hlth, Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, Bethesda, MD 20892 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
CELL LUNG-CANCER; CONVECTION-ENHANCED DELIVERY; INTENSITY FOCUSED ULTRASOUND; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; NECK-CANCER; LIPOSOMAL DOXORUBICIN; CONTRAST AGENT; MESSENGER-RNA; VASCULAR NORMALIZATION;
D O I
10.1038/natrevmats.2017.24
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Advances in nanoparticle synthesis and engineering have produced nanoscale agents affording both therapeutic and diagnostic functions that are often referred to by the portmanteau 'nanotheranostics'. The field is associated with many applications in the clinic, especially in cancer management. These include patient stratification, drug-release monitoring, imaging-guided focal therapy and post-treatment response monitoring. Recent advances in nanotheranostics have expanded this notion and enabled the characterization of individual tumours, the prediction of nanoparticle-tumour interactions, and the creation of tailor-designed nanomedicines for individualized treatment. Some of these applications require breaking the dogma that a nanotheranostic must combine both therapeutic and diagnostic agents within a single, physical entity; instead, it can be a general approach in which diagnosis and therapy are interwoven to solve clinical issues and improve treatment outcomes. In this Review, we describe the evolution and state of the art of cancer nanotheranostics, with an emphasis on clinical impact and translation.
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页数:18
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