Synthesis and Biological Activity of Azaclozodihypyrimidine and Pyrimidine Derivatives

被引：1

作者：

Zhang, Pingzhu ^{[1
]}

Wang, Xiaofen ^{[1
]}

Zheng, Xuevang ^{[1
]}

Lian, Pingping ^{[1
]}

Wei, Chao ^{[1
]}

Li, Xiaoliu ^{[1
]}

机构：

[1] Hebei Univ, Sch Chem & Environm Sci, Minist Educ, Key Lab Chem Biol Hebei Prov,Key Lab Med Chem & M, Baoding 071002, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Knoevenagel reaction; Biginelli reaction; imidazo[1,2-a]dihypyrimidine; imidazo[1,2-a]pyrimidine; triazolo[1,5-a]pyrimidine; CALCIUM-CHANNEL BLOCKERS; POTENT MIMICS; DIHYDROPYRIMIDINES;

D O I：

10.6023/cjoc201804020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel aryl-substituted imidazo[1,2-a]pyrimidine and triazolo[1,5-a] pyrimidine were synthesized by the tandem reaction of Knoevenagel and Atwal modified Biginelli, following by aromatization. Some of their cytotoxic activities against Hela and A549 cells and inhibition for apple tree canker were preliminarily evaluated.

引用

页码：3278 / 3285

页数：8

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