Guest Recognition in a Partially Bridged Deep Cavitand

被引：11

作者：

Busseron, Eric

Rebek, Julius, Jr. ^{[1
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 21期

关键词：

CONTAINER MOLECULES; BINDING; WATER; COMPLEXATION; CHEMISTRY;

D O I：

10.1021/ol101980f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a new deep cavitand partially bridged via disulfide bonds is described. Its thermodynamic and kinetic complexation parameters are compared with those of an unbridged analogue. The disulfide bridges cause deviations in Delta H and Delta S but result in only small differences in Delta G of complexation. The bridges increase the activation barrier for guest dissociation and lead to complexes with enhanced kinetic stability.

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收藏

页码：4828 / 4831

页数：4

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