Psychophysiological prodromal signs of schizophrenic relapse: A pilot study

被引：16

作者：

Dawson, Michael E. ^{[1
]}

Schell, Anne M. ^{[2
]}

Rissling, Anthony ^{[1
]}

Ventura, Joseph ^{[3
]}

Subotnik, Kenneth L. ^{[3
]}

Nuechterlein, Keith H. ^{[3
,4
]}

机构：

[1] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA

[2] Occidental Coll, Dept Psychol, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA

来源：

SCHIZOPHRENIA RESEARCH | 2010年 / 123卷 / 01期

关键词：

Diathesis-stress model; Electrodermal activity; Prodromal signs; Relapse; Schizophrenia; Skin conductance; STRESS MODEL; VULNERABILITY; SYMPTOMS; CRITERIA; EPISODES; ONSET;

D O I：

10.1016/j.schres.2010.07.029

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Do physiological changes occur shortly prior to psychotic relapse in schizophrenia outpatients? We addressed this question in a group of schizophrenia outpatients by measuring changes in symptoms and changes in activation of the sympathetic nervous system, as indexed by changes in skin conductance level (SCL), on a biweekly basis for between one and two years. All six outpatients exhibited heightened SCL within two weeks prior to relapse or exacerbation, compared to SCL proceeding continued remission. These results shed light on the psychotic relapse process and are consistent with neural diathesis-stress models of schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：64 / 67

页数：4

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