A novel and efficient synthesis of 3-iodo substituted 1,8-naphthyridines by electrophilic cyclization of 2-amino nicotinaldehyde and their antimicrobial activity

被引：5
|
作者：
Sakram, B. [1 ]
Ashok, K. [1 ]
Rambabu, S. [1 ]
Sonyanaik, B. [1 ]
Ravi, D. [1 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2017年 / 87卷 / 08期
关键词：
2-aminonicotinaldehyde; electrophilic cyclization; iodine; 1,8-naphthyridine; antimicrobial activity; DERIVATIVES; AGENTS;
D O I：
10.1134/S1070363217080266
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthesis of substituted 1,8-naphthyridines based on 2-aminonicotinaldehyde under mild conditions is studied. Out of three electrophilic iodine sources (I-2, NIS, and ICl) studied, I-2 was determined to act most efficiently in the process. High overall yields were achieved for aliphatic substitution at the reaction center. All compounds were evaluated for antibacterial activity (Staphylococus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia) and anti-fungi activity (Aspergillus flavus and Fusarium oxysporum).
引用
收藏
页码：1794 / 1799
页数：6
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