Pharmacologic augmentation of hypoxia-inducible factor-1α with mimosine boosts the bactericidal capacity of phagocytes

被引：67

作者：

Zinkernagel, Annelies S. ^{[1
]}

Peyssonnaux, Carole ^{[1
,2
]}

Johnson, Randall S. ^{[1
]}

Nizet, Victor ^{[1
]}

机构：

[1] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, Sch Med, Div Pediat Pharmacol & Drug Discovery, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 02期

关键词：

D O I：

10.1086/524843

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hypoxia- inducible factor (HIF)-1 alpha is activated on exposure to bacterial pathogens and regulates the innate immune functions of phagocytes. We show here that the HIF-1 alpha agonist mimosine can boost the capacity of human phagocytes and whole blood to kill the leading pathogen Staphylococcus aureus in a dose-dependent fashion and reduce the lesion size in a murine model of S. aureus skin infection. This provides the first proof of principle for a novel approach to the treatment of bacterial infection by pharmacologically augmenting the host phagocytic cell function.

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页码：214 / 217

页数：4

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