Androgen Receptor Gene CAG Repeat Polymorphism and Breast Cancer Risk in Iranian Women: A Case-Control Study

被引：19

作者：

Mehdipour, Parvin ^{[1
]}

Pirouzpanah, Saeed ^{[1
]}

Kheirollahi, Majid ^{[1
]}

Atri, Morteza ^{[2
,3
]}

机构：

[1] Univ Tehran Med Sci, Dept Med Genet, Sch Med, Tehran 1417613151, Iran

[2] Univ Tehran Med Sci, Inst Canc, Tehran 1417613151, Iran

[3] Day Gen Hosp, Tehran, Iran

来源：

BREAST JOURNAL | 2011年 / 17卷 / 01期

关键词：

androgen receptor; breast cancer; CAG]n repeats; family history; polymorphism; SUSCEPTIBILITY; ASSOCIATION; LENGTH; EXON-1;

D O I：

10.1111/j.1524-4741.2010.01031.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the association between polymorphic expansion of trinucleotide CAG repeats in androgen receptor (AR) gene and breast cancer risk among Iranian women in a matched case-control study. There was a strong overall association between per CAG repeat increments in average repeat length and the risk of the malignancy [OR = 3.56; 95% CI, 2.80-5.29]. Women carrying one or two alleles with [CAG]n repeat >= 22 units were at increased risk of breast cancer [OR = 2.03; 95% CI, 1.56-2.6]. The risk was significantly increased in homozygous longer repeats, versus homozygous alleles < 22. We observed reduced risk of developing the tumor in positive familial breast cancer subjects carrying repeats >= 22 and 23. Homozygosity for the longer [CAG]n repeats may be linked to the increased breast cancer risk. In contrast to previous reports, longer AR [CAG]n repeat alleles may decline the risk among women with a familial breast cancer.

引用

页码：39 / 46

页数：8

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