Mitochondria and Cancer

被引：1316

作者：

Vyas, Sejal ^{[1
]}

Zaganjor, Elma ^{[1
]}

Haigis, Marcia C. ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Cell Biol, Ludwig Ctr Harvard, Boston, MA 02115 USA

来源：

CELL | 2016年 / 166卷 / 03期

关键词：

GLUTAMINE-METABOLISM; CELL-SURVIVAL; OXIDATIVE-PHOSPHORYLATION; REDOX HOMEOSTASIS; PROTEIN-KINASE; TCA CYCLE; MYC; HYPOXIA; GLUTATHIONE; BIOGENESIS;

D O I：

10.1016/j.cell.2016.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in stress sensing to allow for cellular adaptation to the environment. Therefore, it is not surprising that mitochondria are important mediators of tumorigenesis, as this process requires flexibility to adapt to cellular and environmental alterations in addition to cancer treatments. Multiple aspects of mitochondrial biology beyond bioenergetics support transformation, including mitochondrial biogenesis and turnover, fission and fusion dynamics, cell death susceptibility, oxidative stress regulation, metabolism, and signaling. Thus, understanding mechanisms of mitochondrial function during tumorigenesis will be critical for the next generation of cancer therapeutics.

引用

页码：555 / 566

页数：12

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