Characterization, Formation Mechanisms, and pH-Sensitive Drug Release Behavior

被引：58

作者：

Piao, Yongzhe ^{[1
]}

Chen, Biqiong ^{[1
]}

机构：

[1] Univ Sheffield, Dept Mat Sci & Engn, Sheffield S1 3JD, S Yorkshire, England

来源：

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS | 2015年 / 53卷 / 05期

基金：

爱尔兰科学基金会;

关键词：

hydrogel; gelatin; graphene oxide; drug delivery; rheology; GRAPHENE-OXIDE; FUNCTIONALIZED GRAPHENE; GRAPHITE OXIDE; COMPOSITE HYDROGELS; RAMAN-SCATTERING; GELATIN; CHITOSAN; NANOSHEETS; DELIVERY; CARBON;

D O I：

10.1002/polb.23636

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel physically crosslinked graphene oxide (GO)-gelatin nanocomposite hydrogels were obtained by self-assembly. The hydrogels with various ratios of GO to gelatin were prepared, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, and scanning electron microscopy. The static and dynamic rheological properties of the hydrogels were investigated, along with the underlying hydrogel formation mechanisms. The storage modulus of the hydrogels (containing 98-98.5 wt % water) reached 114.5 kPa, owing to the relatively strong physical bonding (i.e., hydrogen bonding and electrostatic forces) between GO and gelatin. Drug release tests showed that the drug release from the hydrogel was pH-dependent, with 96% of the model drug released in a neutral environment, compared to 28% released in an acidic medium. These hydrogels could have potential in pH-sensitive drug delivery. (c) 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 356-367

引用

页码：356 / 367

页数：12

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