Aptamer functionalized nanomaterials for biomedical applications: Recent advances and new horizons

被引：139

作者：

Mahmoudpour, Mansour ^{[1
,2
,3
]}

Ding, Shichao ^{[4
]}

Lyu, Zhaoyuan ^{[4
]}

Ebrahimi, Ghasem ^{[5
]}

Du, Dan ^{[4
]}

Dolatabadi, Jafar Ezzati Nazhad ^{[6
]}

Torbati, Mohammadali ^{[2
]}

Lin, Yuehe ^{[4
]}

机构：

[1] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Food Sci & Technol, Tabriz, Iran

[3] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[4] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA

[5] Tabriz Univ Med Sci, Fac Med Sci, Dept Biochem & Clin Labs, Tabriz, Iran

[6] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

来源：

NANO TODAY | 2021年 / 39卷

关键词：

Nanomaterials; Aptamers; Aptasensor; Biomedical application; METAL-ORGANIC FRAMEWORK; GRAPHENE QUANTUM DOTS; LABEL-FREE DETECTION; SINGLE-ATOM CATALYSTS; ELECTROCHEMICAL APTASENSOR; SENSITIVE DETECTION; ULTRASENSITIVE DETECTION; PLATINUM NANOPARTICLES; SIGNAL AMPLIFICATION; CARBON NANOTUBES;

D O I：

10.1016/j.nantod.2021.101177

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With the advancement of functional nanomaterials and aptamer selection technologies, aptamer functio-nalized nanomaterials (AFMs) open various methods to design new sensing and imaging technologies. In this perspective, several sensitivity-enhancement methods alongside a wide range of smart nanomaterials have been incorporated to construct new AFMs to use in the biomedical field. This review first introduces the conjunction strategies for synthesizing AFMs. Then, the versatile roles of nanomaterials in advanced AFMs are discussed, including optical indicators, conducting transducer, carriers, catalysts, and other functions. Representative examples of biomedical applications are reviewed with emphasis on drug de-livery, bioimaging, and aptasensors. Finally, some challenges and opportunities in this emerging field are presented. (c) 2021 Elsevier Ltd. All rights reserved.

引用

页数：25

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