Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging

被引：11
作者：
Floberg, John M. [1 ]
DeWees, Todd A. [2 ]
Chin, Re-I [3 ]
Garsa, Adam A. [4 ]
Dehdashti, Farrokh [5 ]
Nussenbaum, Brian [6 ]
Oppelt, Peter J. [7 ]
Adkins, Douglas R. [7 ]
Gay, Hiram A. [1 ]
Thorstad, Wade L. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Radiat Oncol, St Louis, MO USA
[2] Mayo Clin, Dept Biomed Stat & Informat, Scottsdale, AZ USA
[3] St Louis Univ, Sch Med, St Louis, MO USA
[4] Univ Southern Calif, Keck Sch Med, Dept Radiat Oncol, Los Angeles, CA USA
[5] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, Div Nucl Med, St Louis, MO USA
[6] Amer Board Otolaryngol, Houston, TX USA
[7] Washington Univ, Sch Med, Dept Internal Med, Div Oncol, St Louis, MO 63110 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2018年 / 40卷 / 10期
关键词：
human papillomavirus (HPV); metabolic tumor volume; oropharyngeal cancer; positron emission tomography; prognostic markers; SQUAMOUS-CELL CARCINOMA; TOTAL LESION GLYCOLYSIS; HUMAN-PAPILLOMAVIRUS; NECK-CANCER; ORAL-CAVITY; T-STAGE; HEAD; RADIOTHERAPY; PET/CT; SURVIVAL;
D O I：
10.1002/hed.25337
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background This study evaluates the prognostic significance of F-18-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. MethodsResultsWe performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. In this 153-patient cohort, stratifying by the optimum MTV (24 cm(3)) was prognostic for FFR (P = .0002), FFDM (P = .001), and OS (P < .0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P = .03), and stage III patients (P = .04). On multivariate analysis only MTV was a significant factor for OS. ConclusionMetabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.
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收藏
页码：2280 / 2287
页数：8
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