Combined optical coherence tomography and electroretinography system for in vivo simultaneous morphological and functional imaging of the rodent retina

被引：9

作者：

Moayed, Alireza Akhlagh ^{[1
]}

Hariri, Sepideh ^{[1
]}

Hyun, Chulho ^{[1
]}

Doran, Bruce ^{[2
]}

Kraft, Timothy W. ^{[3
]}

Boyd, Shelley ^{[4
,5
]}

Bizheva, Kostadinka ^{[1
]}

机构：

[1] Univ Waterloo, Dept Phys & Astron, Waterloo, ON N2L 3G1, Canada

[2] Diagnosys LLC, Lowell, MA 01854 USA

[3] Univ Alabama, Sch Optometry, Dept Vis Sci, Birmingham, AL 35294 USA

[4] St Michaels Hosp, Dept Ophthalmol & Vis Sci, Toronto, ON M5B 1W8, Canada

[5] Univ Toronto, Toronto, ON M5B 1W8, Canada

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2010年 / 15卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

optical coherence tomography; in vivo imaging; retina; functional imaging; electroretinography; RESOLUTION;

D O I：

10.1117/1.3475489

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A combined ultrahigh resolution optical coherence tomography (UHROCT) and a electroretinography (ERG) system is presented for simultaneous imaging of the retinal structure and physiological response to light stimulation in the rodent eye. The 1060-nm UHROCT system provides similar to 3 x 5 mu m (axial x lateral) resolution in the rat retina and time resolution of 22 mu s. A custom-designed light stimulator integrated into the UHROCT imaging probe provides light stimuli with user-selected color, duration, and intensity. The performance of the combined system is demonstrated in vivo in healthy rats, and in a rat model of drug-induced outer retinal degeneration. Experimental results show correlation between the observed structural and physiological changes in the healthy and degenerated retina. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3475489]

引用

页数：3

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