3-Methylene-4-amido-1,2-diazetidine as a Formal 1,4-Dipole Precursor: Lewis Acid-Catalyzed Nucleophilic Addition with Silylated Nucleophiles

被引：14

作者：

Okitsu, Takashi ^{[1
]}

Kobayashi, Keiko ^{[1
]}

Kan, Ryosuke ^{[1
]}

Yoshida, Yuji ^{[1
]}

Matsui, Yuki ^{[1
]}

Wada, Akimori ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Dept Organ Chem Life Sci, Higashinada Ku, 4-19-1 Motoyamakita Machi, Kobe, Hyogo 6588558, Japan

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 17期

关键词：

2+2 CYCLOADDITION REACTION; ORGANIC-SYNTHESIS; OXYALLYL CATIONS; ALLENAMIDES; RING; CYCLOPROPANES; AZETIDINES; ALKENES; DERIVATIVES; CLEAVAGE;

D O I：

10.1021/acs.orglett.7b02194

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Methylene-4-amido-1,2-diazetidine (MADA) was prepared for the first time via formal [2 + 2] cycloaddition of an allenamide and an azodicarboxylate. MADA worked as a formal 1,4-dipole precursor toward nucleophilic addition with various silyl enol ethers and allyltrimethylsilanes.

引用

页码：4592 / 4595

页数：4

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