Intracellularly Biodegradable Polyelectrolyte/Silica Composite Microcapsules as Carriers for Small Molecules
被引:77
作者:
Gao, Hui
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Queen Mary Univ London, Sch Engn & Mat Sci, Mile End Rd, London E1 4NS, EnglandQueen Mary Univ London, Sch Engn & Mat Sci, Mile End Rd, London E1 4NS, England
Gao, Hui
[1
]
Goryacheva, Olga A.
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Saratov NG Chernyshevskii State Univ, 83 Astrakhanskaya St, Saratov 410012, RussiaQueen Mary Univ London, Sch Engn & Mat Sci, Mile End Rd, London E1 4NS, England
Goryacheva, Olga A.
[2
]
Tarakina, Nadezda V.
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Queen Mary Univ London, Sch Engn & Mat Sci, Mile End Rd, London E1 4NS, EnglandQueen Mary Univ London, Sch Engn & Mat Sci, Mile End Rd, London E1 4NS, England
Tarakina, Nadezda V.
[1
]
Sukhorukov, Gleb B.
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Queen Mary Univ London, Sch Engn & Mat Sci, Mile End Rd, London E1 4NS, EnglandQueen Mary Univ London, Sch Engn & Mat Sci, Mile End Rd, London E1 4NS, England
Sukhorukov, Gleb B.
[1
]
机构:
[1] Queen Mary Univ London, Sch Engn & Mat Sci, Mile End Rd, London E1 4NS, England
[2] Saratov NG Chernyshevskii State Univ, 83 Astrakhanskaya St, Saratov 410012, Russia
Microcapsules that can be efficiently loaded with small molecules and effectively released at the target area through the degradation of the capsule shells hold great potential for treating diseases. Traditional biodegradable polyelectrolyte (PE) capsules can be degraded by cells and eliminated from the body but fail to encapsulate drugs with small molecular weight. Here, we report a poly-L-arginine hydrochloride (PARG)/dextran sulfate sodium salt (DEXS)/silica (SiO2) composite capsule that can be destructed in cells and of which the in situ formed inorganic SiO2 enables loading of small model molecules, Rhodamine B (Rh-B). The composite capsules were fabricated based on the layer-by-layer (LbL) technique and the hydrolysis of tetraethoxysilane (TEOS). Capsules composed of non-degradable PEs and SiO2, polyllamine hydrochloride (PAH)/poly-(sodium 4-styrenesulfonate) (PSS)/silica (the control sample), were prepared and briefly compared with the degradable composite capsules. An intracellular degradation study, of both types of composite capsules revealed that PARG/DEXS/silica capsules were degraded into fragments and lead to the release of model molecules in a relatively short time (2 h), while the structure of PAH/PSS/silica capsules remained intact even after 3 days incubation with B50 cells. Such results indicated that the polymer components played a significant role in the degradability of the SiO2. Specifically, PAH/PSS scaffolds blocked the degradation of SiO2. For PARG/DEXS/silica capsules, we proposed the effects of both hydrolytic degradation of amorphous silica and enzymatic degradation of PARG/DEXS polymers as a cell degradation mechanism. All the results demonstrated a new type of functional composite microcapsule with low permeability, good biocompatibility, and biodegradability for potential medical applications.
机构:
Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
Sichuan Univ, W China Hosp, Dept Radiol, Chengdu 610041, Peoples R ChinaSichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA
Winship Canc Inst, Atlanta, GA USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA
机构:
Hungarian Acad Sci, Res Inst Tech Phys & Mat Sci, H-1525 Budapest, HungaryHungarian Acad Sci, Res Inst Tech Phys & Mat Sci, H-1525 Budapest, Hungary
Czigany, Zsolt
;
Hultman, Lars
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机构:
Linkoping Univ, Thin Film Phys Div, Dept Phys Chem & Biol IFM, S-58183 Linkoping, SwedenHungarian Acad Sci, Res Inst Tech Phys & Mat Sci, H-1525 Budapest, Hungary
机构:
Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Ohio State Univ, Coll Pharm, Columbus, OH 43210 USAUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Eloy, Josimar Oliveira
;
de Souza, Marina Claro
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Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
de Souza, Marina Claro
;
Petrilli, Raquel
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机构:
Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Ohio State Univ, Coll Pharm, Columbus, OH 43210 USAUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Petrilli, Raquel
;
Abriata Barcellos, Juliana Palma
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机构:
Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Abriata Barcellos, Juliana Palma
;
Lee, Robert J.
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机构:
Ohio State Univ, Coll Pharm, Columbus, OH 43210 USAUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Lee, Robert J.
;
Marchetti, Juliana Maldonado
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机构:
Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
机构:
Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
Sichuan Univ, W China Hosp, Dept Radiol, Chengdu 610041, Peoples R ChinaSichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
机构:
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA
Winship Canc Inst, Atlanta, GA USAEmory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA
机构:
Hungarian Acad Sci, Res Inst Tech Phys & Mat Sci, H-1525 Budapest, HungaryHungarian Acad Sci, Res Inst Tech Phys & Mat Sci, H-1525 Budapest, Hungary
Czigany, Zsolt
;
Hultman, Lars
论文数: 0引用数: 0
h-index: 0
机构:
Linkoping Univ, Thin Film Phys Div, Dept Phys Chem & Biol IFM, S-58183 Linkoping, SwedenHungarian Acad Sci, Res Inst Tech Phys & Mat Sci, H-1525 Budapest, Hungary
机构:
Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Ohio State Univ, Coll Pharm, Columbus, OH 43210 USAUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Eloy, Josimar Oliveira
;
de Souza, Marina Claro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
de Souza, Marina Claro
;
Petrilli, Raquel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Ohio State Univ, Coll Pharm, Columbus, OH 43210 USAUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Petrilli, Raquel
;
Abriata Barcellos, Juliana Palma
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Abriata Barcellos, Juliana Palma
;
Lee, Robert J.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Coll Pharm, Columbus, OH 43210 USAUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
Lee, Robert J.
;
Marchetti, Juliana Maldonado
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Coll Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil