Isolation and Anti-Inflammatory Activity of Bakuchiol from Ulmus davidiana var. japonica

被引：62

作者：

Choi, Sang Yoon ^{[1
]}

Lee, Sanghyun ^{[2
]}

Choi, Won-Hee ^{[1
]}

Lee, Yeonmi ^{[1
]}

Jo, Youn Ock ^{[1
]}

Ha, Tae-Youl ^{[1
]}

机构：

[1] Korea Food Res Inst, Songnam 463746, South Korea

[2] Chung Ang Univ, Dept Appl Plant Sci, Ansong, South Korea

来源：

JOURNAL OF MEDICINAL FOOD | 2010年 / 13卷 / 04期

关键词：

bakuchiol; nitric oxide; Ulmus davidiana var; japonica; FACTOR-KAPPA-B; NITRIC-OXIDE; PSORALEA-CORYLIFOLIA; MURINE MACROPHAGES; METHANOL EXTRACT; LIPOPOLYSACCHARIDE; MICE; INACTIVATION; INFLAMMATION; INHIBITION;

D O I：

10.1089/jmf.2009.1207

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The bark of the root and stem of Ulmus davidiana var. japonica has been used as a traditional Korean medicine to treat inflammatory disorders. This plant reportedly exhibits antioxidant, anticancer, and anti-inflammatory effects. A search for biologically active compounds in U. davidiana var. japonica extracts yielded bakuchiol, which we structurally identified on the basis of spectral data, including two-dimensional nuclear magnetic resonance spectroscopy and distortionless enhancement by polarization transfer. In our study, bakuchiol ( 50 mu M) inhibited lipopolysaccharide-induced nitric oxide and prostaglandin E-2 production in RAW 264.7 macrophages by 53.7% and 84.2%, respectively. These results suggested that bakuchiol is one of the potent anti-inflammatory components of U. davidiana var. japonica.

引用

收藏

页码：1019 / 1023

页数：5

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