Hemolytic effects of water-soluble fullerene derivatives

被引：93
|
作者：
Bosi, S
Feruglio, L
Da Ros, T
Spalluto, G
Gregoretti, B
Terdoslavich, M
Decorti, G
Passamonti, S
Moro, S
Prato, M
机构：
[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy
[2] Univ Trieste, Dipartimento Sci Biomed, I-34127 Trieste, Italy
[3] Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, I-34127 Trieste, Italy
[4] Univ Padua, Dipartimento Sci Farmaceut, I-35131 Padua, Italy
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 27期
关键词：
D O I：
10.1021/jm0497489
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of water-soluble fullerene C-60 derivatives has been investigated for their cytotoxic and hemolytic properties, with the aim to correlate structure with toxicity. We observed that cationic chains induce significant toxicity while the presence of neutral or anionic moieties did not produce any response in our model. A validation of these experimental observations has been performed by theoretical studies in which hydrophilic and hydrophobic surface areas were correlated quantitatively with hemolytic properties.
引用
收藏
页码：6711 / 6715
页数：5
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