Hepatitis C Core Antigen Testing: A Reliable, Quick, and Potentially Cost-effective Alternative to Hepatitis C Polymerase Chain Reaction in Diagnosing Acute Hepatitis C Virus Infection

被引：57

作者：

Cresswell, Fiona V. ^{[1
]}

Fisher, Martin ^{[1
,2
]}

Hughes, Daniel J. ^{[1
]}

Shaw, Simon G. ^{[1
]}

Homer, Gary ^{[3
]}

Hassan-Ibrahim, Mohammed O. ^{[3
]}

机构：

[1] Royal Sussex Cty Hosp, Lawson Unit, Dept HIV & Sexual Hlth, Brighton BN2 5BE, E Sussex, England

[2] Brighton & Sussex Med Sch, Brighton, E Sussex, England

[3] Royal Sussex Cty Hosp, Dept Virol Microbiol & Infect, Brighton BN2 5BE, E Sussex, England

来源：

CLINICAL INFECTIOUS DISEASES | 2015年 / 60卷 / 02期

关键词：

acute hepatitis C; hepatitis C core antigen; PCR; diagnosis; INDIVIDUALS; ANTIBODY; ASSAY; MEN;

D O I：

10.1093/cid/ciu782

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatitis C virus (HCV) is increasingly common among human immunodeficiency virus (HIV)-infected men who have sex with men. We evaluated the efficacy of HCV core antigen in diagnosing acute HCV in an HIV-infected cohort. Compared with HCV polymerase chain reaction, core antigen proved sensitive (100%) and specific (97.9%). As a quick, simple, and cost-effective test, it has considerable utility in screening for acute HCV.

引用

页码：263 / 266

页数：4

共 12 条

[1] Acute hepatitis C in HIV-infected individuals: recommendations from the European AIDS Treatment Network (NEAT) consensus conference The European AIDS Treatment Network (NEAT) Acute Hepatitis C Infection Consensus Panel [J].

Albert, Matthieu ;

Benito, Jose ;

Bhagani, Sanjay ;

Boesecke, Christoph ;

Deterding, Katja ;

Dominguez, Stephanie ;

Fisher, Martin ;

Fontanet, Arnaud ;

Garcia, Diego ;

Gilson, Richard ;

Guiguet, Marguerite ;

Hoepelman, Andy I. M. ;

Horban, Andrzej ;

Katlama, Christine ;

Mallolas, Josep ;

Page, Emma ;

Peters, Lars ;

Pozniak, Anton ;

Prins, Maria ;

Puoti, Massimo ;

Rauch, Andri ;

Rodger, Alison ;

Rockstroh, Juergen K. ;

Soriano, Vincent ;

Stephan, Christoph ;

Thibault, Vincent ;

Tural, Cristina ;

Valantin, Marc-Antoine ;

van de Laar, Thijs ;

van der Meer, Jan ;

Vella, Stefano ;

Vogel, Martin ;

de Wit, Stephane ;

Autran, Brigitte ;

Clotet, Bonaventura ;

Danta, Mark ;

Journiac, Maxime ;

Matthews, Gail ;

Meyer-Olson, Dirk ;

Nelson, Mark ;

Schmidt, Reinhold ;

Wedemeyer, Heiner .

AIDS, 2011, 25 (04) :399-409

[2] British HIV Association guidelines for the routine investigation and monitoring of adult HIV-1-infected individuals 2011 [J].

Asboe, D. ;

Aitken, C. ;

Boffito, M. ;

Booth, C. ;

Cane, P. ;

Fakoya, A. ;

Geretti, A. M. ;

Kelleher, P. ;

Mackie, N. ;

Muir, D. ;

Murphy, G. ;

Orkin, C. ;

Post, F. ;

Rooney, G. ;

Sabin, C. ;

Sherr, L. ;

Smit, E. ;

Tong, W. ;

Ustianowski, A. ;

Valappil, M. ;

Walsh, J. ;

Williams, M. ;

Yirrell, D. .

HIV MEDICINE, 2012, 13 (01) :1-44

[3]

Carney R, 2014, HIV MED, V15, P8

[4] Hepatitis C virus core antigen assay: can we think beyond convention in resource limited settings? [J].

Chakravarti, Anita ;

Chauhan, Mayank S. ;

Dogra, Gaurav ;

Banerjee, Sayantan .

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, 2013, 17 (03) :369-374

[5]

Feirer DS, 2010, CURR INFECT DIS REP, V12, P118

[6]

Infectious Diseases Society of America, GUID PREV TREATM OPP

[7] Characteristics and Treatment Outcomes among HIV-Infected Individuals in the Australian Trial in Acute Hepatitis C [J].

Matthews, G. V. ;

Hellard, M. ;

Haber, P. ;

Yeung, B. ;

Marks, P. ;

Baker, D. ;

McCaughan, G. ;

Sasadeusz, J. ;

White, P. ;

Rawlinson, W. ;

Lloyd, A. ;

Kaldor, J. ;

Dore, G. J. .

CLINICAL INFECTIOUS DISEASES, 2009, 48 (05) :650-658

[8] Hepatitis C virus core antigen: Analytical performances, correlation with viremia and potential applications of a quantitative, automated immunoassay [J].

Medici, Maria Cristina ;

Furlini, Giuliano ;

Rodella, Anna ;

Fuertes, Antonio ;

Monachetti, Alessia ;

Calderaro, Adriana ;

Galli, Silvia ;

Terlenghi, Luigina ;

Olivares, Magdalena ;

Bagnarelli, Patrizia ;

Costantini, Andrea ;

De Conto, Flora ;

Sainz, Maria ;

Galli, Claudio ;

Manca, Nino ;

Landini, Maria Paola ;

Dettori, Giuseppe ;

Chezzi, Carlo .

JOURNAL OF CLINICAL VIROLOGY, 2011, 51 (04) :260-265

[9] Diagnosing acute hepatitis C in HIV-infected patients: Nucleic acid testing compared with antibody and antigen-antibody detecting methods [J].

Nastouli, Eleni ;

Thomson, Emma C. ;

Karayiannis, Peter ;

Main, Janice ;

McClure, Myra ;

Muir, David .

JOURNAL OF CLINICAL VIROLOGY, 2009, 44 (01) :78-80

[10] Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV [J].

Thomson, Emma C. ;

Nastouli, Eleni ;

Main, Janice ;

Karayiannis, Peter ;

Eliahoo, Joseph ;

Myra, David Muir ;

McClure, Myra O. .

AIDS, 2009, 23 (01) :89-93

← 1 2 →