Synthesis and biological evaluation of novel lipid A antagonists

被引：21

作者：

Peri, F

Marinzi, C

Barath, M

Granucci, F

Urbano, M

Nicotra, F

机构：

[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, I-20126 Milan, Italy

[2] Slovak Acad Sci, Inst Chem, Bratislava 84538, Slovakia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.bmc.2005.08.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A mimetic of Lipid A with a beta-N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its beta-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflammatory activity. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：190 / 199

页数：10

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