Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

被引：57

作者：

Baumann, M. ^{[1
]}

Baxendale, Ian R. ^{[1
]}

机构：

[1] Univ Durham, Dept Chem, South Rd, Durham DH1 3LE, England

来源：

REACTION CHEMISTRY & ENGINEERING | 2016年 / 1卷 / 02期

关键词：

ACTIVE PHARMACEUTICAL INGREDIENTS; ENABLING TECHNOLOGY; ORGANIC-SYNTHESIS; CHEMISTRY; ELECTROCHEMISTRY; ARTEMISININ; WINDOWS;

D O I：

10.1039/c5re00037h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new enabling technology for performing photochemical reactions in a continuous fashion is presented. This photo-reactor is compatible with existing flow systems and can be furthermore linked to a photo-spectrometer in order to allow for real time analysis of photochemical reactions. In this communication we wish to report the profiling of this system and its application to the continuous synthesis of ibuprofen based on a photo-Favorskii rearrangement reaction of a readily available a-chloropropiophenone precursor.

引用

页码：147 / 150

页数：4