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A Method of Obtaining Silver-Succinyl Chitosan Nanocomposites and their Antimicrobial Activity
被引:0
作者:
Aleksandrova, V. A.
[1
]
Futoryanskaya, A. M.
[1
]
Sadykova, V. S.
[2
]
机构:
[1] Russian Acad Sci, Topchiev Inst Petrochem Synth, Moscow 119991, Russia
[2] Gause Inst New Antibiot, Moscow 119021, Russia
关键词:
silver nanoparticles;
chitosan;
succinyl-chitosan;
antimicrobial activity;
green synthesis;
NANOPARTICLES;
D O I:
10.1134/S0003683822050040
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
To form silver nanoparticles by reduction from metal ions in the presence of a reducing agent, D-glucose, a water-soluble derivative of chitosan, succinyl-chitosan, was used as a polymer matrix at room temperature. The synthesis of silver nanoparticles can also be carried out without a reducing agent by thermal activation of the system using an alkali (NaOH) as an accelerator. The presence of silver nanoparticles in the obtained colloidal solutions was judged by the appearance of an absorption band in the electron plasmon resonance spectra (ƛ(max) = 417 nm). It has been shown that the use of an additional component, polyethylene oxide, in a macromolecular system makes it possible to obtain small silver nanoparticles (1-3 nm). The results of in vitro studies of the antimicrobial activity of the obtained colloidal solutions containing silver nanoparticles confirm that a decrease in the size of silver nanoparticles leads to an expansion of the spectrum of antibacterial activity of strains of gram-positive and gram-negative bacteria (B. subtilis ATCC 6633, S. aureus 209P, E. coli ATCC 25922) and to the manifestation of a pronounced antifungal action in relation to A. niger INA 00760.
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页码:641 / 645
页数:5
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