A Comparative Study of Oral Cyclosporine and Betamethasone Minipulse Therapy in the Treatment of Alopecia Areata

被引：13

作者：

Jang, Yong Hyun ^{[1
]}

Kim, Sang Lim ^{[1
]}

Lee, Kyou Chae ^{[1
]}

Kim, Min Ji ^{[1
]}

Park, Kyung Hea ^{[1
]}

Lee, Weon Ju ^{[1
]}

Lee, Seok-Jong ^{[1
]}

Kim, Do Won ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Dermatol, 130 Dongdeok Ro, Daegu 41944, South Korea

来源：

ANNALS OF DERMATOLOGY | 2016年 / 28卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Alopecia areata; Betamethasone; Comparative study; Cyclosporine; Pulse drug therapy; METHYLPREDNISOLONE;

D O I：

10.5021/ad.2016.28.5.569

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Various systemic agents have been assessed for the treatment of alopecia areata (AA); however, there is a; paucity of comparative studies. Objective: To assess and compare cyclosporine and betamethasone minipulse therapy as treatments for AA with regard to effectiveness and, safety. Methods: Data were collected from 88 patients who. received at least 3 months of oral cyclosporine (n = 51) or betamethasone minipulse therapy (n = 37) for AA. Patients with >= 50% of terminal hair regrowth in the alopecic area were considered responders. Results: The responder of the cyclo-sporine group was 54.9% and that of the betamethasone minipulse group was 37.8%. In the cyclosporine group, patients with mild AA were found to respond better to the treatment. Based on the patient self-assessments, 70.6% of patients in the cyclosporine group and 43.2% of patients in the betamethasone minipulse group rated their hair regrowth as excellent or good. Side effects were less frequent in the cyclosporine group. Conclusion: Oral cyclosporine appeared to be superior to betamethasone minipulse therapy in terms of treatment effectiveness and safety.

引用

页码：569 / 574

页数：6

共 23 条

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