Molecular Probes for Imaging Fibrosis and Fibrogenesis

被引：48
作者：
Desogere, Pauline [1 ,2 ,3 ]
Montesi, Sydney B. [4 ]
Caravan, Peter [1 ,2 ,3 ]
机构：
[1] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[2] Harvard Med Sch, Charlestown, MA 02129 USA
[3] Massachusetts Gen Hosp, Inst Innovat Imaging, Dept Radiol, Boston, MA 02128 USA
[4] Massachusetts Gen Hosp, Div Pulm & Crit Care, Boston, MA 02114 USA
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2019年 / 25卷 / 05期
关键词：
collagen; fibrogenesis; fibrosis; imaging agents; medicinal chemistry; IDIOPATHIC PULMONARY-FIBROSIS; MATRIX-METALLOPROTEINASE ACTIVITY; MRI CONTRAST AGENT; LIVER FIBROSIS; CROSS-LINKING; CORONARY-THROMBOSIS; RENAL FIBROSIS; LYSYL OXIDASE; COLLAGEN; ELASTIN;
D O I：
10.1002/chem.201801578
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a common result of chronic tissue injury. Advances in the clinical management of fibrotic diseases have been hampered by the low sensitivity and specificity of noninvasive early diagnostic options, lack of surrogate end points for use in clinical trials, and a paucity of noninvasive tools to assess fibrotic disease activity longitudinally. Hence, the development of new methods to image fibrosis and fibrogenesis is a large unmet clinical need. Herein, an overview of recent and selected molecular probes for imaging of fibrosis and fibrogenesis by magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography is provided.
引用
收藏
页码：1128 / 1141
页数：14
相关论文
共 112 条
  • [1] New Therapeutic Targets in Idiopathic Pulmonary Fibrosis Aiming to Rein in Runaway Wound-Healing Responses
    Ahluwalia, Neil
    Shea, Barry S.
    Tager, Andrew M.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 190 (08) : 867 - 878
  • [2] 68Ga-DOTANOC PET/CT Allows Somatostatin Receptor Imaging in Idiopathic Pulmonary Fibrosis: Preliminary Results
    Ambrosini, Valentina
    Zompatori, Maurizio
    De Luca, Fiorella
    Antonia, D'Errico
    Allegri, Vincenzo
    Nanni, Cristina
    Malvi, Deborah
    Tonveronachi, Eva
    Fasano, Luca
    Fabbri, Mario
    Fanti, Stefano
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (12) : 1950 - 1955
  • [3] Collagen interactions: Drug design and delivery
    An, Bo
    Lin, Yu-Shan
    Brodsky, Barbara
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2016, 97 : 69 - 84
  • [4] Measurement of Tissue Interstitial Volume in Healthy Patients and Those with Amyloidosis with Equilibrium Contrast-enhanced MR Imaging
    Bandula, Steve
    Banypersad, Sanjay M.
    Sado, Daniel
    Flett, Andrew S.
    Punwani, Shonit
    Taylor, Stuart A.
    Hawkins, Philip N.
    Moon, James C.
    [J]. RADIOLOGY, 2013, 268 (03) : 858 - 864
  • [5] Activation of somatostatin receptors attenuates pulmonary fibrosis
    Borie, R.
    Fabre, A.
    Prost, F.
    Marchal-Somme, J.
    Lebtahi, R.
    Marchand-Adam, S.
    Aubier, M.
    Soler, P.
    Crestani, B.
    [J]. THORAX, 2008, 63 (03) : 251 - 258
  • [6] NATURE AND LOCATION OF INTRAMOLECULAR CROSS-LINKS IN COLLAGEN
    BORNSTEIN, P
    KANG, AH
    PIEZ, KA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 55 (02) : 417 - +
  • [7] In Vivo Assessment of Aortic Aneurysm Wall Integrity Using Elastin-Specific Molecular Magnetic Resonance Imaging
    Botnar, Rene M.
    Wiethoff, Andrea J.
    Ebersberger, Ullrich
    Lacerda, Sara
    Blume, Ulrike
    Warley, Alice
    Jansen, Christian H. P.
    Onthank, David C.
    Cesati, Richard R.
    Razavi, Reza
    Marber, Michael S.
    Hamm, Bernd
    Schaeffter, Tobias
    Robinson, Simon P.
    Makowski, Marcus R.
    [J]. CIRCULATION-CARDIOVASCULAR IMAGING, 2014, 7 (04) : 679 - U173
  • [8] In vivo magnetic resonance imaging of coronary thrombosis using a fibrin-binding molecular magnetic resonance contrast agent
    Botnar, RM
    Buecker, A
    Wiethoff, AJ
    Parsons, EC
    Katoh, M
    Katsimaglis, G
    Weisskoff, RM
    Lauffer, RB
    Graham, PB
    Gunther, RW
    Manning, WJ
    Spuentrup, E
    [J]. CIRCULATION, 2004, 110 (11) : 1463 - 1466
  • [9] Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease
    Brilla, CG
    Funck, RC
    Rupp, H
    [J]. CIRCULATION, 2000, 102 (12) : 1388 - 1393
  • [10] LEAKY VESSELS, FIBRIN DEPOSITION, AND FIBROSIS - A SEQUENCE OF EVENTS COMMON TO SOLID TUMORS AND TO MANY OTHER TYPES OF DISEASE
    BROWN, LF
    DVORAK, AM
    DVORAK, HF
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 140 (04): : 1104 - 1107
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