Molecular Probes for Imaging Fibrosis and Fibrogenesis

被引：48

作者：

Desogere, Pauline ^{[1
,2
,3
]}

Montesi, Sydney B. ^{[4
]}

Caravan, Peter ^{[1
,2
,3
]}

机构：

[1] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[2] Harvard Med Sch, Charlestown, MA 02129 USA

[3] Massachusetts Gen Hosp, Inst Innovat Imaging, Dept Radiol, Boston, MA 02128 USA

[4] Massachusetts Gen Hosp, Div Pulm & Crit Care, Boston, MA 02114 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2019年 / 25卷 / 05期

关键词：

collagen; fibrogenesis; fibrosis; imaging agents; medicinal chemistry; IDIOPATHIC PULMONARY-FIBROSIS; MATRIX-METALLOPROTEINASE ACTIVITY; MRI CONTRAST AGENT; LIVER FIBROSIS; CROSS-LINKING; CORONARY-THROMBOSIS; RENAL FIBROSIS; LYSYL OXIDASE; COLLAGEN; ELASTIN;

D O I：

10.1002/chem.201801578

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a common result of chronic tissue injury. Advances in the clinical management of fibrotic diseases have been hampered by the low sensitivity and specificity of noninvasive early diagnostic options, lack of surrogate end points for use in clinical trials, and a paucity of noninvasive tools to assess fibrotic disease activity longitudinally. Hence, the development of new methods to image fibrosis and fibrogenesis is a large unmet clinical need. Herein, an overview of recent and selected molecular probes for imaging of fibrosis and fibrogenesis by magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography is provided.

引用

页码：1128 / 1141

页数：14

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