Growth inhibition of capsaicin on HeLa cells is not mediated by intracellular calcium mobilization

被引：23

作者：

Takahata, K

Chen, XY

Tada, M

机构：

[1] Okayama Univ, Fac Agr, Okayama 7008530, Japan

[2] Okayama Univ, Fac Agr, Okayama 700, Japan

来源：

LIFE SCIENCES | 1999年 / 64卷 / 13期

关键词：

capsaicin; capsazepine; HeLa cells; cell growth; intracellular calcium; BAPTA/AM;

D O I：

10.1016/S0024-3205(99)00046-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of capsaicin on cellular growth and intracellular calcium mobilization were examined in human cervical carcinoma derivation, HeLa cells. Capsaicin inhibited cellular growth and increased intracellular calcium level in HeLa cells. This capsaicin-induced intracellular calcium concentration rise was blocked by capsazepin, vanilloid (capsaicin) receptor antagonist. But, an intracellular calcium chelator BAPTA/AM did not block the inhibitory effect of capsaicin on cellular growth. These observations suggest that intracellular calcium mobilization is not required for the capsaicin-induced inhibition of cellular growth. (C) 1999 Elsevier Science Inc.

引用

页码：PL165 / PL171

页数：7

共 21 条

[1] THE EFFECTS OF LOCALLY APPLIED CAPSAICIN ON CONDUCTION IN CUTANEOUS NERVES IN 4 MAMMALIAN-SPECIES [J].